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肺炎:诊断与治疗的最新进展

Pneumonia: Recent Updates on Diagnosis and Treatment.

作者信息

Khan Maaz Ahsan, Bajwa Awais, Hussain Syed Talal

机构信息

Department of Internal Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA.

Department of Pulmonary, Critical Care & Sleep Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA.

出版信息

Microorganisms. 2025 Feb 27;13(3):522. doi: 10.3390/microorganisms13030522.

DOI:10.3390/microorganisms13030522
PMID:40142415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11945699/
Abstract

Pneumonia remains a leading cause of mortality internationally, making it an intense area of study for new tools for diagnosis and treatment. In this review, we evaluate the potential of recently emerging syndromic panels in promoting rapid diagnosis and improved antibiotic stewardship. We will also examine emerging treatments, including new antibiotics in a world of worsening antimicrobial resistance, in addition to new methods of delivery and non-antibiotic paths of treatment.

摘要

肺炎仍然是全球主要的死亡原因之一,这使其成为诊断和治疗新工具的重点研究领域。在本综述中,我们评估了最近出现的症状组合检测在促进快速诊断和改善抗生素管理方面的潜力。我们还将研究新兴的治疗方法,包括在抗菌药物耐药性日益严重的情况下的新型抗生素,以及新的给药方法和非抗生素治疗途径。

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本文引用的文献

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Multiplex real-time PCR in non-invasive respiratory samples to reduce antibiotic use in community-acquired pneumonia: a randomised trial.非侵入性呼吸道样本的多重实时聚合酶链反应可减少社区获得性肺炎的抗生素使用:一项随机试验。
Nat Commun. 2024 Aug 17;15(1):7098. doi: 10.1038/s41467-024-51547-8.
2
The efficacy and safety of inhaled antibiotics for pneumonia: A systematic review and meta-analysis.吸入性抗生素治疗肺炎的疗效和安全性:系统评价和荟萃分析。
Pulm Pharmacol Ther. 2024 Sep;86:102315. doi: 10.1016/j.pupt.2024.102315. Epub 2024 Jul 14.
3
Phage therapy: breathing new tactics into lower respiratory tract infection treatments.噬菌体疗法:为下呼吸道感染治疗注入新策略。
Eur Respir Rev. 2024 Jun 26;33(172). doi: 10.1183/16000617.0029-2024. Print 2024 Apr.
4
Utility of a multiplex pathogen detection system directly from respiratory specimens for treatment and diagnostic stewardship.从呼吸道标本直接进行多重病原体检测系统对治疗和诊断管理的效用。
Microbiol Spectr. 2024 Jun 4;12(6):e0375923. doi: 10.1128/spectrum.03759-23. Epub 2024 May 7.
5
The agreement between bronchoalveolar lavage, bronchial wash and sputum culture: a retrospective study.支气管肺泡灌洗、支气管冲洗和痰培养之间的一致性:一项回顾性研究。
Infection. 2024 Aug;52(4):1481-1488. doi: 10.1007/s15010-024-02238-5. Epub 2024 Apr 8.
6
Microbial aetiology of community-acquired pneumonia in hospitalised adults: A prospective study utilising comprehensive molecular testing.成人社区获得性肺炎的微生物病因学:一项利用综合分子检测的前瞻性研究。
Int J Infect Dis. 2024 Jun;143:107019. doi: 10.1016/j.ijid.2024.107019. Epub 2024 Apr 4.
7
Diagnostic Stewardship in Community-Acquired Pneumonia With Syndromic Molecular Testing: A Randomized Clinical Trial.症状分子检测在社区获得性肺炎中的诊断管理:一项随机临床试验。
JAMA Netw Open. 2024 Mar 4;7(3):e240830. doi: 10.1001/jamanetworkopen.2024.0830.
8
Combination eravacycline therapy for ventilator-associated pneumonia due to carbapenem-resistant Acinetobacter baumannii in patients with COVID-19: A case series.COVID-19 患者耐碳青霉烯鲍曼不动杆菌呼吸机相关性肺炎的依拉环素联合治疗:一项病例系列研究。
Pharmacotherapy. 2024 Apr;44(4):301-307. doi: 10.1002/phar.2908. Epub 2024 Jan 25.
9
Impact of different corticosteroids on severe community-acquired pneumonia: a systematic review and meta-analysis.不同糖皮质激素治疗重症社区获得性肺炎的影响:系统评价和荟萃分析。
BMJ Open Respir Res. 2024 Jan 22;11(1):e002141. doi: 10.1136/bmjresp-2023-002141.
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Heterogeneity of Benefit from Earlier Time-to-Antibiotics for Sepsis.抗生素治疗时机提前对脓毒症获益的异质性。
Am J Respir Crit Care Med. 2024 Apr 1;209(7):852-860. doi: 10.1164/rccm.202310-1800OC.