Zhang Cheng, Li Jiaming, Cui Huan, Jin Yifei, Chen Zhaoliang, Zhang Lei, Song Sihui, Lu Bing, Wang Zhongyi, Guo Zhendong
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 573 Tulip Street, Changchun 130122, China.
State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 573 Tulip Street, Changchun 130122, China.
Microorganisms. 2025 Mar 5;13(3):597. doi: 10.3390/microorganisms13030597.
Lentinan (LNT) was found to reduce the aerosol transmission rate between golden hamsters from 100% (9/9) to 44.4% (4/9). The viral loads in the respiratory system, including the nasal turbinate, trachea, and lung, were significantly reduced in the infected golden hamsters that received LNT treatment. Furthermore, the amount of exhaled virus aerosols in hamsters treated with LNT was significantly lower than that in untreated hamsters throughout the entire disease progression. In detail, the amounts of virus-laden particles with aerodynamic diameters less than 5 µm exhibited a significant decreasing trend following LNT treatment. Moreover, the detection rate of infectious SARS-CoV-2 in each stage of the Anderson-6 sampler exhibited a decreasing trend following LNT treatment post-infection. In summary, our findings indicate that LNT therapy represents a promising therapeutic candidate for the treatment of COVID-19 patients. Meanwhile, during the course of treatment, LNT has the potential to reduce viral infectivity in affected individuals.
香菇多糖（LNT）被发现可将金黄仓鼠之间的气溶胶传播率从100%（9/9）降低至44.4%（4/9）。在接受LNT治疗的受感染金黄仓鼠中，包括鼻甲、气管和肺在内的呼吸系统中的病毒载量显著降低。此外，在整个疾病进展过程中，接受LNT治疗的仓鼠呼出的病毒气溶胶量明显低于未治疗的仓鼠。具体而言，空气动力学直径小于5 µm的载病毒颗粒数量在LNT治疗后呈现出显著下降趋势。此外，感染后接受LNT治疗后，安德森-6级采样器各阶段传染性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的检出率呈下降趋势。总之，我们的研究结果表明，LNT疗法是治疗新冠肺炎患者的一种有前景的治疗候选方案。同时，在治疗过程中，LNT有可能降低受感染个体的病毒传染性。
