Bhargava Ashish, Klamer Katherine, Sharma Mamta, Ortiz Daniel, Saravolatz Louis
Thomas Mackey Center of Infectious Diseases, Henry Ford Health-St. John Hospital, Detroit, MI 48236, USA.
School of Medicine, Wayne State University, Detroit, MI 48202, USA.
Microorganisms. 2025 Mar 13;13(3):652. doi: 10.3390/microorganisms13030652.
is a World Health Organization critical-priority fungal pathogen that has variable resistance to antifungal treatments. Multiple clades have been identified through genomic analysis and have appeared in different geographic locations simultaneously. Due to a combination of factors including antifungal resistance, ability to colonize and persist in the environment, and thermotolerance, it can thrive. Infected patients are associated with a high mortality rate, especially those with multiple health risk factors like those associated with other species. This review highlights the current situation of this pathogen to help provide guidance for future work.
是一种世界卫生组织认定的关键优先真菌病原体，对抗真菌治疗具有不同程度的耐药性。通过基因组分析已鉴定出多个进化枝，且它们同时出现在不同地理位置。由于包括抗真菌耐药性、在环境中定殖和存活的能力以及耐热性等多种因素的综合作用，它能够大量繁殖。感染患者的死亡率很高，尤其是那些有多种健康风险因素的患者，就像感染其他物种相关病原体的患者一样。本综述强调了这种病原体的现状，以帮助为未来的工作提供指导。
