Eix Emily F, Nett Jeniel E
Department of Medicine and Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA; email:
Annu Rev Med. 2025 Jan;76(1):57-67. doi: 10.1146/annurev-med-061523-021233. Epub 2025 Jan 16.
is a recently emerged fungal pathogen that causes severe infections in healthcare settings around the globe. A feature that distinguishes from other fungal pathogens is its high capacity to colonize skin, leading to widespread outbreaks in healthcare facilities via patient-to-patient transmission. can persist on skin or in the surrounding environment for extended periods of time, and it exhibits greater antifungal resistance than other species. These factors pose major obstacles for the prevention and treatment of infection. Recent reports have identified frequently colonized skin sites, risk factors for developing invasive infection, and patterns of antifungal resistance among strains, all of which help guide therapeutic options. In this review, we highlight key studies of epidemiology and antifungal resistance, discussing how these factors influence healthcare-associated transmission and treatment outcomes.
是一种最近出现的真菌病原体，在全球医疗机构中引起严重感染。与其他真菌病原体不同的一个特征是其在皮肤上定殖的能力很强，通过患者之间的传播在医疗机构中导致广泛的暴发。它可以在皮肤或周围环境中长期存活，并且比其他物种表现出更强的抗真菌耐药性。这些因素对感染的预防和治疗构成了重大障碍。最近的报告已经确定了经常定殖的皮肤部位、发生侵袭性感染的危险因素以及菌株中的抗真菌耐药模式，所有这些都有助于指导治疗选择。在这篇综述中，我们重点介绍了关于该病原体流行病学和抗真菌耐药性的关键研究，讨论了这些因素如何影响医疗相关传播和治疗结果。
需注意，原文中多次出现未明确的指代，翻译时按“该病原体”等表述处理，实际应用中应结合具体所指对象准确翻译。
