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小脑成熟畸胎瘤伴颅外成分形成

Mature Teratoma of the Cerebellum with Formed Extracranial Component.

作者信息

Nowacka Agnieszka, Ziółkowska Ewa, Smuczyński Wojciech, Bożiłow Dominika, Śniegocki Maciej

机构信息

Department of Neurosurgery, Collegium Medicum in Bydgoszcz, Nicolas Copernicus University in Toruń, ul. Curie Skłodowskiej 9, 85-094 Bydgoszcz, Poland.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

J Clin Med. 2025 Mar 15;14(6):1994. doi: 10.3390/jcm14061994.

Abstract

Intracranial teratomas are very rare in adults, representing only 0.3-0.5% of all primary brain tumors. They originate from all three germ layers, and are classified as mature, immature, or malignant. Mature teratomas constitute the most prevalent type in the adult population, commonly originating from midline structures such as the pineal and suprasellar regions. However, the localization of these tumors within the cerebellum is exceedingly rare, with only a limited number of cases reported globally. In this manuscript, we describe, to the best of our knowledge, the first documented case of a young adult patient presenting with a mature teratoma situated between the cerebellar hemispheres. Notably, this tumor was accompanied by occipital bone loss, through which a tumor pedicle extended, forming an extracranial component. : After analyzing the clinical picture and additional examinations, the patient was classified for surgery. The intracranial part of the tumor contained numerous cysts with yellow fluid, a tooth, and fat tissue. The tumor was removed radically, with its extracranial part. : On the fourth day after surgery, the patient was discharged from the clinic in a good general condition, walking, with marked cerebellar symptoms. In a follow-up at 6 months postoperatively, the neurological examination was normal, with no headaches. MRI at the 6 months follow-up did not show any residual or recurrent tumor. Histopathological examination confirmed the diagnosis of mature teratoma.

摘要

颅内畸胎瘤在成人中非常罕见,仅占所有原发性脑肿瘤的0.3%-0.5%。它们起源于所有三个胚层,分为成熟型、未成熟型或恶性型。成熟畸胎瘤是成人中最常见的类型,通常起源于中线结构,如松果体和鞍上区域。然而,这些肿瘤位于小脑内的情况极为罕见,全球仅报道了少数病例。在本手稿中,据我们所知,我们描述了首例有文献记载的年轻成年患者,其小脑半球之间存在成熟畸胎瘤。值得注意的是,该肿瘤伴有枕骨缺损,肿瘤蒂由此延伸,形成颅外部分。:在分析临床情况和进一步检查后,该患者被分类进行手术。肿瘤的颅内部分包含许多含有黄色液体的囊肿、一颗牙齿和脂肪组织。肿瘤及其颅外部分被彻底切除。:术后第四天,患者以良好的一般状况从诊所出院,能够行走,但有明显的小脑症状。术后6个月随访时,神经学检查正常,无头痛。术后6个月的MRI检查未显示任何残留或复发肿瘤。组织病理学检查证实为成熟畸胎瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2381/11943208/a63fa60b71cb/jcm-14-01994-g001.jpg

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