Sato Satoshi, Iino Chikara, Furusawa Keisuke, Yoshida Kenta, Chinda Daisuke, Sawada Kaori, Mikami Tatsuya, Nakaji Shigeyuki, Fukuda Shinsaku, Sakuraba Hirotake
Department of Gastroenterology, Hematology, and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Division of Endoscopy, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
J Clin Med. 2025 Mar 16;14(6):2013. doi: 10.3390/jcm14062013.
This study investigated the relationship between the composition of oral microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD) in the general population. In total, 712 participants in a health check-up project were divided into four oral microbiota patterns by principal component analysis and cluster analysis; they were included in , , , and groups. The group had the largest number of patients and was used as a reference group to compare the incidence of MASLD and cardiometabolic criteria with the other groups. In a multivariate analysis, the group was a risk factor for MASLD independent of cardiometabolic criteria compared with the group. The correlation between oral bacterial species and MASLD-related items showed that was negatively correlated with controlled attenuation parameters, body mass index, waist circumference, hemoglobin A1c, alanine aminotransferase, and fatty liver index. showed a positive correlation with controlled attenuation parameters, waist circumference, body mass index, blood pressure, triglycerides, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, and fatty liver index, and a negative correlation with high-density lipoprotein cholesterol. In contrast, the and groups were not clearly associated with MASLD. Maintaining oral hygiene and preventing periodontitis may contribute to preventing MASLD and extending a healthy lifespan.
本研究调查了普通人群口腔微生物群组成与代谢功能障碍相关脂肪性肝病（MASLD）之间的关系。在一项健康检查项目中，共有712名参与者通过主成分分析和聚类分析被分为四种口腔微生物群模式；他们被纳入A、B、C和D组。A组患者数量最多，被用作参考组，以比较其他组的MASLD发病率和心脏代谢标准。在多变量分析中，与A组相比，C组是独立于心脏代谢标准的MASLD危险因素。口腔细菌种类与MASLD相关指标之间的相关性表明，D与受控衰减参数、体重指数、腰围、糖化血红蛋白、丙氨酸氨基转移酶和脂肪肝指数呈负相关。C与受控衰减参数、腰围、体重指数、血压、甘油三酯、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶和脂肪肝指数呈正相关，与高密度脂蛋白胆固醇呈负相关。相比之下，B组和D组与MASLD没有明显关联。保持口腔卫生和预防牙周炎可能有助于预防MASLD并延长健康寿命。
