Csecsei Peter, Bogdan Agnes, Molnar Tihamer, Zavori Laszlo, Schwarcz Attila, Lenzser Gabor
Department of Neurosurgery, Medical School, University of Pecs, 7624 Pecs, Hungary.
Department of Medical Biology, Medical School, University of Pecs, 7624 Pecs, Hungary.
J Clin Med. 2025 Mar 18;14(6):2056. doi: 10.3390/jcm14062056.
Aneurysmal subarachnoid hemorrhage (aSAH) is a disease associated with high mortality, caused by the rupture of a cerebral aneurysm. Decision-support scoring systems used for managing unruptured aneurysms (UIAs) include only radiological parameters related to the size and configuration of the aneurysm, without incorporating blood-based markers. Our aim is to identify a serum marker that shows a correlation with aneurysm size in patients with ruptured aneurysms. : Arterial blood samples were collected from patients who experienced aSAH within 24 h of the ictus, and serum desmosine levels were determined using ELISA. The morphological parameters of the aneurysms were assessed during 3D DSA. A favorable outcome was defined as a 3-month mRS score of 0-3. : This study included 135 aSAH patients and 25 controls. (i) The desmosine level in serum collected within 24 h after aneurysm rupture in patients with aSAH was significantly higher compared to the serum level in the control group (aSAH: 0.737 ng/mL [IQR: 0.401-1.214], vs. control: 0.365 ng/mL [IQR: 0.251-0.531], < 0.001); (ii) examining the size of ruptured aneurysms, patients with aneurysms larger than 7 mm had significantly higher serum desmosine levels than those with aneurysms smaller than 7 mm; (iii) in the group with aneurysms smaller than 7 mm, serum desmosine levels correlated with the aneurysm neck width and the size ratio. : Serum desmosine shows a strong correlation with the size of ruptured aneurysms in aSAH patients.
动脉瘤性蛛网膜下腔出血（aSAH）是一种由脑动脉瘤破裂引起的、死亡率很高的疾病。用于管理未破裂动脉瘤（UIA）的决策支持评分系统仅包括与动脉瘤大小和形态相关的放射学参数，未纳入血液标志物。我们的目的是确定一种与破裂动脉瘤患者的动脉瘤大小相关的血清标志物。：在发病后24小时内从经历aSAH的患者中采集动脉血样本，并使用酶联免疫吸附测定法（ELISA）测定血清中锁链素水平。在三维数字减影血管造影（3D DSA）期间评估动脉瘤的形态学参数。良好结局定义为3个月改良Rankin量表（mRS）评分为0 - 3分。：本研究纳入了135例aSAH患者和25例对照。（i）aSAH患者动脉瘤破裂后24小时内采集的血清中锁链素水平显著高于对照组血清水平（aSAH：0.737 ng/mL [四分位间距：0.401 - 1.214]，对照组：0.365 ng/mL [四分位间距：0.251 - 0.531]，< 0.001）；（ii）检查破裂动脉瘤的大小，动脉瘤大于7 mm的患者血清锁链素水平显著高于动脉瘤小于7 mm的患者；（iii）在动脉瘤小于7 mm的组中，血清锁链素水平与动脉瘤颈部宽度和大小比相关。：血清锁链素与aSAH患者破裂动脉瘤的大小密切相关。
