Nicolaescu Oana Elena, Belu Ionela, Mocanu Andreea Gabriela, Manda Valentin Costel, Rău Gabriela, Pîrvu Andreea Silvia, Ionescu Cătălina, Ciulu-Costinescu Felicia, Popescu Mariana, Ciocîlteu Maria Viorica
Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Dolj County, Romania.
Department of Instrumental and Analytical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349 Craiova, Dolj County, Romania.
Pharmaceutics. 2025 Feb 22;17(3):288. doi: 10.3390/pharmaceutics17030288.
Cyclodextrins (CDs) have revolutionized the pharmaceutical industry with their ability to enhance the stability, solubility, and bioavailability of a wide range of active substances. These cyclic oligosaccharides, with a unique hydrophilic exterior and hydrophobic cavity, form inclusion complexes with poorly soluble drugs, improving their pharmacokinetic profiles and therapeutic efficacy. This review explores the multifaceted roles of cyclodextrins in pharmaceutical formulations, ranging from oral, ophthalmic, parenteral, and topical applications to their emerging use in targeted therapies, gene delivery, and treatment of neurodegenerative, cardiovascular, and infectious diseases. Cyclodextrins not only improve drug solubility and controlled release but also reduce toxicity and side effects, leading to safer and more effective treatments. Recent advancements, such as cyclodextrin-based nanoparticles, offer promising pathways for cancer therapy, chronic disease management, and personalized medicine. As research continues, cyclodextrins remain at the forefront of innovation in drug delivery systems, ensuring better patient outcomes and expanding the possibilities of modern therapeutics.
环糊精（CDs）凭借其增强多种活性物质稳定性、溶解性和生物利用度的能力，给制药行业带来了变革。这些环状寡糖具有独特的亲水性外部和疏水性内腔，能与难溶性药物形成包合物，改善其药代动力学特征和治疗效果。本综述探讨了环糊精在药物制剂中的多方面作用，涵盖口服、眼科、肠胃外和局部应用，以及它们在靶向治疗、基因递送、神经退行性疾病、心血管疾病和传染病治疗中的新兴用途。环糊精不仅能提高药物溶解度和控制释放，还能降低毒性和副作用，从而实现更安全、有效的治疗。基于环糊精的纳米颗粒等最新进展为癌症治疗、慢性病管理和个性化医疗提供了有前景的途径。随着研究的持续进行，环糊精在药物递送系统创新中始终处于前沿，确保更好的患者治疗效果，并拓展现代治疗的可能性。
