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两亲性环糊精作为治疗用途载体的潜力：简要概述。

The Potential of Amphiphilic Cyclodextrins as Carriers for Therapeutic Purposes: A Short Overview.

作者信息

Pârvănescu Ramona Daniela, Păpurică Marius, Alexa Ionica Oana, Dehelean Cristina Adriana, Șoica Codruța, Moacă Elena Alina, Ledeți Adriana, Voicu Mirela, Coricovac Dorina, Trandafirescu Cristina

机构信息

Research Center for Experimental Pharmacology and Drug Design, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, RO-300041 Timișoara, Romania.

University Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, RO-300041 Timișoara, Romania.

出版信息

Pharmaceutics. 2025 Aug 21;17(8):1086. doi: 10.3390/pharmaceutics17081086.

DOI:10.3390/pharmaceutics17081086
PMID:40871103
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12389205/
Abstract

Cyclodextrins, since their discovery in the late 19th century, have gained tremendous interest in biomedical research, beginning with their recognition as safe pharmaceutical excipients, and continuing with exploiting their potential for enhancing the therapeutic response of active pharmaceutical ingredients, and also to be used as drugs for specific medical purposes. This review presents an integrative perspective on amphiphilic cyclodextrins, the manuscript being divided into two parts, one devoted to the properties of amphiphilic cyclodextrins, while the second one is dedicated to their biomedical applications, with an emphasis on cancer therapy.

摘要

自19世纪末被发现以来，环糊精在生物医学研究中引起了极大的关注。最初，它们被认为是安全的药用辅料，随后人们开始探索其增强活性药物成分治疗效果的潜力，并且它们还被用作特定医疗用途的药物。本综述提供了关于两亲性环糊精的综合观点，文章分为两部分，一部分专门介绍两亲性环糊精的性质，另一部分则致力于其生物医学应用，重点是癌症治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/3ee39f875437/pharmaceutics-17-01086-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/beb49af3629c/pharmaceutics-17-01086-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/3b48c81686ff/pharmaceutics-17-01086-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/fb2f8e13e3c3/pharmaceutics-17-01086-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/6b24bc92a82b/pharmaceutics-17-01086-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/16be39df97f8/pharmaceutics-17-01086-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/d3f317c617f2/pharmaceutics-17-01086-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/ff981abe01dd/pharmaceutics-17-01086-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/3ee39f875437/pharmaceutics-17-01086-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/beb49af3629c/pharmaceutics-17-01086-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/3b48c81686ff/pharmaceutics-17-01086-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/fb2f8e13e3c3/pharmaceutics-17-01086-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/6b24bc92a82b/pharmaceutics-17-01086-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/16be39df97f8/pharmaceutics-17-01086-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/d3f317c617f2/pharmaceutics-17-01086-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/ff981abe01dd/pharmaceutics-17-01086-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a893/12389205/3ee39f875437/pharmaceutics-17-01086-g008.jpg

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本文引用的文献

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Cyclodextrins as Multifunctional Platforms in Drug Delivery and Beyond: Structural Features, Functional Applications, and Future Trends.环糊精作为药物递送及其他领域的多功能平台：结构特征、功能应用及未来趋势
Molecules. 2025 Jul 20;30(14):3044. doi: 10.3390/molecules30143044.
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A recent update of water-soluble polymers in cyclodextrin-based formulations for mucosal drug delivery.基于环糊精的黏膜给药制剂中水溶性聚合物的最新进展。
Carbohydr Polym. 2025 Jun 15;358:123539. doi: 10.1016/j.carbpol.2025.123539. Epub 2025 Mar 26.
3
Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy.
基于环糊精和壳聚糖的智能药物递送系统用于癌症治疗
Pharmaceuticals (Basel). 2025 Apr 13;18(4):564. doi: 10.3390/ph18040564.
4
Cyclodextrins as multifunctional tools for advanced biomaterials in tissue repair and regeneration.环糊精作为用于组织修复和再生的先进生物材料的多功能工具。
Bioact Mater. 2025 Mar 27;49:627-651. doi: 10.1016/j.bioactmat.2025.03.018. eCollection 2025 Jul.
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Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics.环糊精：提升现代治疗药物的递送、溶解度及生物利用度。
Pharmaceutics. 2025 Feb 22;17(3):288. doi: 10.3390/pharmaceutics17030288.
6
Cyclodextrin-based delivery systems for chemical and genetic drugs: Current status and future.用于化学药物和基因药物的环糊精基递送系统：现状与未来。
Carbohydr Polym. 2025 Mar 15;352:123174. doi: 10.1016/j.carbpol.2024.123174. Epub 2024 Dec 24.
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Structure-activity relationship of modified amphiphilic cationic cyclodextrins for enhanced siRNA delivery.用于增强siRNA递送的修饰两亲性阳离子环糊精的构效关系
Int J Pharm. 2025 Feb 10;670:125107. doi: 10.1016/j.ijpharm.2024.125107. Epub 2024 Dec 19.
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Anti-inflammatory effects of cyclodextrin nanoparticles enable macrophage repolarization and reduce inflammation.环糊精纳米颗粒的抗炎作用可使巨噬细胞重新极化并减轻炎症。
Discov Nano. 2024 Dec 21;19(1):211. doi: 10.1186/s11671-024-04175-6.
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Cyclodextrins: Advances in Chemistry, Toxicology, and Multifaceted Applications.环糊精：化学、毒理学和多方面应用的进展。
Molecules. 2024 Nov 12;29(22):5319. doi: 10.3390/molecules29225319.
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Advancements in cyclodextrin-based controlled drug delivery: Insights into pharmacokinetic and pharmacodynamic profiles.基于环糊精的控释药物递送的进展：对药代动力学和药效学特征的见解。
Heliyon. 2024 Oct 30;10(21):e39917. doi: 10.1016/j.heliyon.2024.e39917. eCollection 2024 Nov 15.