两亲性环糊精作为治疗用途载体的潜力：简要概述。

The Potential of Amphiphilic Cyclodextrins as Carriers for Therapeutic Purposes: A Short Overview.

作者信息

Pârvănescu Ramona Daniela, Păpurică Marius, Alexa Ionica Oana, Dehelean Cristina Adriana, Șoica Codruța, Moacă Elena Alina, Ledeți Adriana, Voicu Mirela, Coricovac Dorina, Trandafirescu Cristina

机构信息

Research Center for Experimental Pharmacology and Drug Design, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, RO-300041 Timișoara, Romania.

University Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, RO-300041 Timișoara, Romania.

出版信息

Pharmaceutics. 2025 Aug 21;17(8):1086. doi: 10.3390/pharmaceutics17081086.

DOI:10.3390/pharmaceutics17081086

PMID:40871103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12389205/

Abstract

Cyclodextrins, since their discovery in the late 19th century, have gained tremendous interest in biomedical research, beginning with their recognition as safe pharmaceutical excipients, and continuing with exploiting their potential for enhancing the therapeutic response of active pharmaceutical ingredients, and also to be used as drugs for specific medical purposes. This review presents an integrative perspective on amphiphilic cyclodextrins, the manuscript being divided into two parts, one devoted to the properties of amphiphilic cyclodextrins, while the second one is dedicated to their biomedical applications, with an emphasis on cancer therapy.

摘要

自19世纪末被发现以来，环糊精在生物医学研究中引起了极大的关注。最初，它们被认为是安全的药用辅料，随后人们开始探索其增强活性药物成分治疗效果的潜力，并且它们还被用作特定医疗用途的药物。本综述提供了关于两亲性环糊精的综合观点，文章分为两部分，一部分专门介绍两亲性环糊精的性质，另一部分则致力于其生物医学应用，重点是癌症治疗。