Alkhaldi Muzn, Sengupta Soma, Keck Cornelia M
Department of Pharmaceutics and Biopharmaceutics, Philipps-Universität Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.
Pharmaceutics. 2025 Feb 25;17(3):301. doi: 10.3390/pharmaceutics17030301.
: This study provided a comparison of the influence of each component of the microemulsion formulation and investigated the impact of varying concentrations of the microemulsion components on curcumin's ability to penetrate the skin using an ex vivo porcine ear model. : Curcumin microemulsions with different compositions were prepared and analyzed for their physicochemical properties. The dermal penetration efficacy of curcumin was evaluated from the different formulations and compared with non-microemulsion formulations. : Findings proved that microemulsion formulations improve the dermal penetration efficacy for curcumin when compared with non-microemulsion formulations. The composition of the microemulsion affects the penetration efficacy of curcumin and increases with decreasing oil content and increasing surfactant and water content. The best penetration for curcumin is achieved with a microemulsion that contained 7.7 g of medium-chain triglycerides as the oil phase, 6.92 g of Tween 80 and 62.28 g of ethanol as the surfactant mixture, and 23.1 g water. : The present study provides a foundational basis for further development of different microemulsion formulations for enhancing the dermal penetration of poorly water-soluble active compounds.
本研究比较了微乳剂配方各成分的影响，并使用离体猪耳模型研究了微乳剂成分不同浓度对姜黄素透皮能力的影响。制备了不同组成的姜黄素微乳剂，并对其理化性质进行了分析。从不同配方评估姜黄素的皮肤渗透效果，并与非微乳剂配方进行比较。研究结果证明，与非微乳剂配方相比，微乳剂配方可提高姜黄素的皮肤渗透效果。微乳剂的组成会影响姜黄素的渗透效果，且随着油相含量降低、表面活性剂和水相含量增加而提高。当微乳剂含有7.7 g中链甘油三酯作为油相、6.92 g吐温80和62.28 g乙醇作为表面活性剂混合物以及23.1 g水时，姜黄素的渗透效果最佳。本研究为进一步开发不同微乳剂配方以增强难溶性活性化合物的皮肤渗透提供了基础依据。
