基于树突状细胞衍生外泌体的药物递送系统

Drug Delivery Systems Based on Dendritic-Cell-Derived Exosomes.

作者信息

Chen Lihua, Zhang Jie, Huang Yueyan, Zhang Xiaoqin, Zhang Guoqing, Kong Shuaizhi, Gao Jianqing, Zhang Xiaojuan, Ding Baoyue

机构信息

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.

Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, No. 118 Jiahang Road, Jiaxing 314001, China.

出版信息

Pharmaceutics. 2025 Mar 3;17(3):326. doi: 10.3390/pharmaceutics17030326.

DOI:10.3390/pharmaceutics17030326

PMID:40142991

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11946698/

Abstract

Exosomes, spherical lipid-bilayered particles secreted by cells, have recently emerged as a novel and highly promising drug delivery system, attracting extensive attention in the field of biomedical research. Dendritic-cell-derived exosomes (DC-Exos) possess surface protein and ligands characteristic of DC cells, such as functional MHC-I and MHC-II, CD80, CD86. These components play a crucial role in immune responses, facilitating antigen uptake, presentation, and the activation of antigen-specific CD4 and CD8 T cells. These properties make them striking and excellent drug delivery vehicles for use in various immune diseases and cancer therapy. This review summarizes and discusses the characteristics, current methods and types of drug loading of DC-Exos. Its surface modifications and application in disease treatment were also discussed, aiming to motivate the development of exosome-based theranostic nanoplatforms and nanotechnology for improved healthcare treatments.

摘要

外泌体是细胞分泌的球形脂质双分子层颗粒，最近已成为一种新型且极具前景的药物递送系统，在生物医学研究领域引起了广泛关注。树突状细胞衍生的外泌体（DC-Exos）具有DC细胞特有的表面蛋白和配体，如功能性MHC-I和MHC-II、CD80、CD86。这些成分在免疫反应中起关键作用，有助于抗原摄取、呈递以及抗原特异性CD4和CD8 T细胞的激活。这些特性使其成为用于各种免疫疾病和癌症治疗的引人注目的优秀药物递送载体。本文综述并讨论了DC-Exos的特性、当前的药物负载方法和类型。还讨论了其表面修饰及其在疾病治疗中的应用，旨在推动基于外泌体的治疗诊断纳米平台和纳米技术的发展，以改善医疗保健治疗。