Sberna Giuseppe, Bordi Licia, Mija Cosmina, Girardi Enrico, Maggi Fabrizio, Lalle Eleonora
Laboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Viruses. 2025 Mar 20;17(3):452. doi: 10.3390/v17030452.
The global outbreak of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the strategies adopted by different nations have affected and altered the transmission of different respiratory pathogens around the world. We examined the impact of SARS-CoV-2 on the spread of respiratory viruses in the period between 2021 and 2024 in patients with severe influenza-like symptoms in the Lazio region using multiplex PCR tests for the identification of common seasonal respiratory viruses. Our data reveal a change in the transmission of respiratory viruses from 2021 to 2024, with a sharp decline in the transmission of SARS-CoV-2 and a rise in the transmission of other respiratory viruses, especially influenza viruses, and human rhinovirus/enterovirus in 2024. Moreover, viral co-infections, both those involving two viruses and those involving three viruses, have also increased. This work shows how the spread of SARS-CoV-2 influenced the spread of other respiratory viruses over four years in patients with severe influenza-like symptoms in the Lazio region. In conclusion, the resurgence and fluctuation of various respiratory viruses emphasize the dynamic nature of viral epidemiology in the post-pandemic context and highlight the ongoing need for vigilant public health monitoring and intervention strategies.
严重急性呼吸综合征相关冠状病毒2（SARS-CoV-2）的全球爆发以及不同国家采取的策略，已经影响并改变了世界各地不同呼吸道病原体的传播。我们使用多重PCR检测来鉴定常见的季节性呼吸道病毒，研究了2021年至2024年期间SARS-CoV-2对拉齐奥地区出现严重流感样症状患者中呼吸道病毒传播的影响。我们的数据显示，2021年至2024年期间呼吸道病毒的传播发生了变化，SARS-CoV-2的传播急剧下降，而其他呼吸道病毒的传播有所上升，尤其是2024年的流感病毒和人鼻病毒/肠道病毒。此外，涉及两种病毒和三种病毒的病毒合并感染也有所增加。这项研究表明，在拉齐奥地区出现严重流感样症状的患者中，SARS-CoV-2的传播如何在四年时间里影响了其他呼吸道病毒的传播。总之，各种呼吸道病毒的卷土重来和波动凸显了大流行后背景下病毒流行病学的动态性质，并突出了持续进行警惕的公共卫生监测和干预策略的必要性。
