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合并性炎症:同时发生的肌炎和多发性神经病作为一项诊断挑战

Converging Inflammations: Simultaneous Myositis and Polyneuropathy as a Diagnostic Challenge.

作者信息

Kumari Shikha, Priyanka Gudimetla, N C Kiran, Bansal Rachit, Sharma Siddharth

机构信息

General Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.

出版信息

Cureus. 2025 Feb 23;17(2):e79536. doi: 10.7759/cureus.79536. eCollection 2025 Feb.

DOI:10.7759/cureus.79536
PMID:40144419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11942522/
Abstract

Idiopathic inflammatory myopathies consist of a variety of autoimmune diseases with variable clinical manifestations, treatment response, and prognosis. Symmetrical proximal predominant muscle weakness is the usual presenting clinical manifestation except in the case of clinically amyopathic dermatomyositis and inclusion body myositis, which represent without muscle weakness and asymmetric muscle weakness, respectively. Other extramuscular manifestations include skin rash and necrosis, arthritis, interstitial lung disease, myocarditis, dysphagia, and Raynaud's phenomenon. However, there are only a few case reports of neuromyositis in the literature. Here, we describe a case of a 30-year-old Indian male patient with polymyositis associated with inflammatory polyneuropathy.

摘要

特发性炎性肌病由多种自身免疫性疾病组成,临床表现、治疗反应和预后各不相同。除临床无肌病性皮肌炎和包涵体肌炎分别表现为无肌无力和不对称肌无力外,对称性近端为主的肌无力是常见的临床表现。其他肌肉外表现包括皮疹和坏死、关节炎、间质性肺病、心肌炎、吞咽困难和雷诺现象。然而,文献中关于神经肌炎的病例报告很少。在此,我们描述一例30岁印度男性患者,患有与炎性多发性神经病相关的多发性肌炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/ca7c831bff21/cureus-0017-00000079536-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/61fcce05fd1f/cureus-0017-00000079536-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/9febbb4c4a15/cureus-0017-00000079536-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/ca7c831bff21/cureus-0017-00000079536-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/61fcce05fd1f/cureus-0017-00000079536-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/9febbb4c4a15/cureus-0017-00000079536-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05b5/11942522/ca7c831bff21/cureus-0017-00000079536-i03.jpg

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本文引用的文献

1
Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome.同时合并肌炎、炎性多发性神经病和重叠性重症肌无力综合征
Case Rep Neurol Med. 2016;2016:6108234. doi: 10.1155/2016/6108234. Epub 2016 Dec 1.
2
Myopathy and neuropathy with pipestem capillaries and vascular activated complement deposition.伴有管状毛细血管和血管激活补体沉积的肌病和神经病。
Neurology. 2011 Jul 26;77(4):401-3. doi: 10.1212/WNL.0b013e3182267bb1. Epub 2011 Jul 13.
3
Adult dermatomyositis with severe polyneuropathy: does neuromyositis exist?
成人皮肌炎伴严重多发性神经病:存在神经肌炎吗?
Neurol Sci. 2010 Jun;31(3):373-6. doi: 10.1007/s10072-010-0246-0. Epub 2010 Mar 13.
4
Dermatomyositis with peripheral nervous system involvement: activation of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) in vasculitic lesions.伴发周围神经系统受累的皮肌炎:血管炎性病变中血管内皮生长因子(VEGF)及VEGF受体(VEGFR)的激活
Intern Med. 2003 Dec;42(12):1233-9. doi: 10.2169/internalmedicine.42.1233.