Mathis Stéphane, Magy Laurent, Corcia Philippe, Ghorab Karima, Richard Laurence, Ciron Jonathan, Duchesne Mathilde, Vallat Jean-Michel
Department of Neurology, Nerve-Muscle Unit, CHU Bordeaux (Groupe Hospitalier Pellegrin), place Amélie-Raba-Léon, 33000 Bordeaux, France.
Department of Neurology, Centre de Référence "Neuropathies Périphériques Rares", CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France.
Case Rep Neurol Med. 2016;2016:6108234. doi: 10.1155/2016/6108234. Epub 2016 Dec 1.
Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies). For each patient, we carried out a pathological analysis (nerve and muscle) and an electrophysiological study (and follow-up). To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.
免疫介导的神经肌肉疾病包括周围神经系统、神经肌肉接头和肌肉的病变。如果认识到重叠综合征（或几乎两种自身免疫性疾病的关联），那么几种自身免疫性神经肌肉疾病同时出现的情况是罕见的。我们描述了两名同时出现炎性神经病变、肌炎和重症肌无力（乙酰胆碱受体抗体阳性）的患者。对于每名患者，我们都进行了病理分析（神经和肌肉）和电生理研究（以及随访）。据我们所知，这是对这种三联免疫介导的神经肌肉综合征的首次描述。我们将我们的观察结果与其他几例同时诊断出两种炎性神经肌肉疾病的病例进行了比较。
