Yates Tristan, Sigwebela Siphumelele, Seedat Soraya, Milham Michael, du Plessis Stefan, Abramson Lior, Niemiec Erica, Worthman Carol, Rotheram-Borus Mary Jane, Salum Giovanni, Franco Alexandre, Zuanazzi Arianna, Ahmed Fatima, Gemmell Kelly, Christodoulou Joan, Mhlaba Nomandla, Mqhele Noluncedo, Ngalimane Nomfusi, Sambudla Akhona, Tottenham Nim, Tomlinson Mark
Department of Psychology, Columbia University, New York, New York.
Institute for Life Course Health Research, Department of Global Health, Stellenbosch University, Cape Town, South Africa.
Biol Psychiatry Glob Open Sci. 2025 Jan 31;5(3):100457. doi: 10.1016/j.bpsgos.2025.100457. eCollection 2025 May.
Understanding the neurobiology of resilient emotion regulation following adversities is critical for addressing mental health problems globally. However, the functional neurobiology of resilience has rarely been studied in low- and middle-income countries, which comprise 90% of the world's population and experience more consistent adversities. Here, we describe how we are investigating the neurodevelopment of resilient emotion regulation in adolescents (anticipated = 525) from a South African birth cohort recruited from a low-income, high-adversity township. Across 2 longitudinal time points (13-14 and 15-16 years), magnetic resonance imaging, behavior, and self-report measures from adolescents and their caregivers are collected. These data are complemented by existing developmental histories (from the prenatal period to 8 years). The culturally adapted measures, protocols, and analytic plans for investigating resilient emotion regulation are presented. By characterizing neurodevelopmental correlates of adolescent resilience from an understudied low- and middle-income country, this research will provide deeper insights into mental health globally.
了解逆境后情绪弹性调节的神经生物学对于解决全球心理健康问题至关重要。然而，在占世界人口90%且面临更多持续性逆境的低收入和中等收入国家，情绪弹性的功能性神经生物学很少得到研究。在此，我们描述了我们如何正在对来自南非一个低收入、高逆境城镇招募的出生队列中的青少年（预计525名）的情绪弹性调节的神经发育进行研究。在两个纵向时间点（13至14岁和15至16岁），收集了青少年及其照顾者的磁共振成像、行为和自我报告测量数据。这些数据由现有的发育史（从孕期到8岁）补充。还介绍了用于研究情绪弹性调节的经过文化适应的测量方法、方案和分析计划。通过刻画一个研究不足的低收入和中等收入国家青少年情绪弹性的神经发育相关因素，这项研究将为全球心理健康提供更深入的见解。
