遗传性α-胰蛋白酶血症与血管痉挛性心绞痛相关性的首例证明：病例报告
First demonstration of implication of hereditary alpha-tryptasaemia in vasospastic angina: a case report.
作者信息
Caullery Benoit, Bocquet Alexis, Riou Laurent, Barone-Rochette Gilles
机构信息
Department of Cardiology, University Hospital, Grenoble 38000, France.
Internal Medicine Department, University Hospital, Grenoble 38000, France.
出版信息
Eur Heart J Case Rep. 2025 Mar 15;9(3):ytaf130. doi: 10.1093/ehjcr/ytaf130. eCollection 2025 Mar.
BACKGROUND
Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored.
CASE SUMMARY
A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease.
DISCUSSION
The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.
背景
变异性心绞痛是一种常见病症。对于治疗反应不佳的病例，应探寻较罕见的病因。
病例摘要
一名患有变异性心绞痛的50岁女性被诊断出对治疗的反应存在显著波动且原因不明，这引发了对过敏现象的怀疑。诊断为遗传性α-色胺血症，引入第二代H1抗组胺药后有效控制了先前难治的变异性冠状动脉疾病。
讨论
该病例首次表明遗传性α-色胺血症与变异性心绞痛有关。未来需要进行病理生理学研究以进一步探索这两种病症之间的联系。
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