Sasaki Ayako, Kadowaki Tomoka, Matsumoto Naomi, Mitsuhashi Toshiharu, Takao Soshi, Yorifuji Takashi
Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
GHM Open. 2024 Jul 31;4(1):52-53. doi: 10.35772/ghmo.2023.01018.
We examined the association between antibody titer levels and risk of coronavirus disease 2019 (COVID-19) infection in the general Japanese population, including a total of 1,972 participants between June and September 2022. Specifically, we ascertained participantsIgG antibody titers targeting the spike protein and infection status, and subsequently examined the association between antibody titer categories (< 2,500, 2,500-5,000, 5,000-10,000 and > 10,000 AU/mL) and COVID-19 infection to estimate risk ratios (RR) and their 95% confidence intervals (CI). Compared to the lowest category, the adjusted RR for participants with antibody titers ≥ 10,000 AU/mL was 0.38 (95% CI: 0.20-0.71). The observed non-linear relationship between the titers and the risk of infection showed that the risk decreased as the participant's antibody titer increased, but the slope became milder when the antibody titer reached approximately 10,000 AU/mL. These findings may contribute to the use of an individual's antibody titer to consider appropriate timing of vaccination.
我们研究了日本普通人群中抗体滴度水平与2019冠状病毒病（COVID-19）感染风险之间的关联，研究对象包括2022年6月至9月期间的1972名参与者。具体而言，我们确定了参与者针对刺突蛋白的IgG抗体滴度和感染状况，随后检查了抗体滴度类别（<2500、2500 - 5000、5000 - 10000和>10000 AU/mL）与COVID-19感染之间的关联，以估计风险比（RR）及其95%置信区间（CI）。与最低类别相比，抗体滴度≥10000 AU/mL的参与者的调整后RR为0.38（95% CI：0.20 - 0.71）。观察到的滴度与感染风险之间的非线性关系表明，随着参与者抗体滴度的增加，风险降低，但当抗体滴度达到约10000 AU/mL时，斜率变缓。这些发现可能有助于利用个体的抗体滴度来考虑适当的疫苗接种时间。
