Rottura Michelangelo, Barbieri Maria Antonietta, Siniscalchi Carmine, Di Micco Pierpaolo, Drago Selene Francesca Anna, Gigliotti De Fazio Marianna, Cicero Arrigo Francesco Giuseppe, Fogacci Federica, Armentaro Giuseppe, Sciacqua Angela, Arcoraci Vincenzo, Irrera Natasha, Imbalzano Egidio
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Department of Medicine and Surgery, University of Parma, Parma, Italy.
Front Med (Lausanne). 2025 Mar 12;12:1521344. doi: 10.3389/fmed.2025.1521344. eCollection 2025.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases circulating LDL levels and cardiovascular disease (CVD) risk; its levels may be related to the dysregulation of glycemic control and may be affected by estrogens. The aim of this study was to assess factors related to PCSK9 levels, and to evaluate the correlation between PCSK9 levels and CV parameters in post-menopausal diabetic women in primary prevention.
Generalized linear models (GLM) were adopted to evaluate predictors of PCSK9 levels as well as factors related to CV outcomes, such as pulse wave velocity (PWV), pulse pressure (PP), and augmentation index (AI).
A total of 135 post-menopausal diabetic women, with a median (Q1-Q3) serum PCSK9 levels of 370.3 (344.0-409.4) ng/ml were enrolled. Apolipoprotein B values resulted an independent predictor of PCSK9 levels ( = 1.023; 0.001). However, LDL values were inversely related to PCSK9 levels ( = -0.578; 0.001). PCSK9 levels influenced PWV ( = 0.010; 0.010), but did not influence other CV outcomes.
ApoB and LDL may influence PCSK9 levels and PCSK9 directly influence PWV in post-menopausal diabetic women in primary prevention. Therefore, the relationship between PCSK9 and primary prevention cannot be excluded, thus highlighting its role as biomarker of CV risk.
前蛋白转化酶枯草溶菌素/kexin 9型（PCSK9）可升高循环低密度脂蛋白水平并增加心血管疾病（CVD）风险；其水平可能与血糖控制失调有关，且可能受雌激素影响。本研究旨在评估与PCSK9水平相关的因素，并评价绝经后糖尿病女性一级预防中PCSK9水平与心血管参数之间的相关性。
采用广义线性模型（GLM）评估PCSK9水平的预测因素以及与心血管结局相关的因素，如脉搏波速度（PWV）、脉压（PP）和增强指数（AI）。
共纳入135例绝经后糖尿病女性，血清PCSK9水平中位数（Q1-Q3）为370.3（344.0-409.4）ng/ml。载脂蛋白B值是PCSK9水平的独立预测因素（ = 1.023； 0.001）。然而，低密度脂蛋白值与PCSK9水平呈负相关（ = -0.578； 0.001）。PCSK9水平影响脉搏波速度（ = 0.010； 0.010），但不影响其他心血管结局。
在一级预防的绝经后糖尿病女性中，载脂蛋白B和低密度脂蛋白可能影响PCSK9水平，且PCSK9直接影响脉搏波速度。因此，不能排除PCSK9与一级预防之间的关系，从而突出了其作为心血管风险生物标志物的作用。
