Huang Anwu, Lin Bin, Ji Xiaojun, Chen Shanjiang
Department of Cardiology, Wenzhou Central Hospital, Wenzhou, Zhejiang, China.
Front Cardiovasc Med. 2025 Mar 12;12:1421364. doi: 10.3389/fcvm.2025.1421364. eCollection 2025.
Herpes simplex virus-1 (HSV-1) is a recognised pathogen that is primarily associated with skin mucosal infection. However, in rare cases, it has been observed to lead to skin extramucosal manifestations, including myocarditis. The present case report documents the occurrence of severe myocarditis in a 35-year-old female patient, attributed to HSV-1 infection. She received cardiac support in the form of VA-ECMO (Venoarterial Extracorporeal Membrane Oxygenation). Concurrently, the patient exhibited cutaneous manifestations of erythema multiforme, which demonstrated a favourable response to antiviral and hormonal therapy. This case underscores the significance of HSV-1 as a causative agent of myocarditis and underscores the necessity for vigilance and expeditious treatment of potential cardiac complications caused by HSV-1.
单纯疱疹病毒1型（HSV-1）是一种公认的病原体，主要与皮肤黏膜感染有关。然而，在罕见情况下，已观察到它会导致皮肤黏膜外表现，包括心肌炎。本病例报告记录了一名35岁女性患者因HSV-1感染发生严重心肌炎的情况。她接受了VA-ECMO（静脉动脉体外膜肺氧合）形式的心脏支持。同时，该患者出现了多形红斑的皮肤表现，对抗病毒和激素治疗反应良好。本病例强调了HSV-1作为心肌炎病原体的重要性，并强调了对HSV-1引起的潜在心脏并发症保持警惕和迅速治疗的必要性。
