Kendler K S, Gruenberg A M, Tsuang M T
Am J Psychiatry. 1985 Jul;142(7):827-32. doi: 10.1176/ajp.142.7.827.
The authors examine the long-term stability of the subtypes of schizophrenia defined by four diagnostic systems. When all patients were considered, agreement between subtype assigned at index and follow-up was modest. This agreement increased considerably when only patients diagnosed as paranoid, hebephrenic, or catatonic at both index and follow-up were considered. As for individual subtypes, stability was highest for paranoid schizophrenia, intermediate for hebephrenia, and virtually absent for undifferentiated schizophrenia. The stability of paranoid schizophrenia was greatest when onset occurred after age 30. As length of follow-up increased, a larger proportion of patients were diagnosed as undifferentiated or residual.
作者们研究了由四种诊断系统所定义的精神分裂症亚型的长期稳定性。当考虑所有患者时，初次诊断时所分配的亚型与随访时的一致性一般。当仅考虑在初次诊断和随访时均被诊断为偏执型、青春型或紧张型的患者时，这种一致性显著提高。至于个体亚型，偏执型精神分裂症的稳定性最高，青春型居中，未分化型精神分裂症几乎不存在稳定性。偏执型精神分裂症在30岁以后发病时稳定性最强。随着随访时间的延长，更大比例的患者被诊断为未分化型或残留型。
