Beratis S, Gabriel J, Hoidas S
Dept. of Psychiatry, University of Patras Medical School, Greece.
Schizophr Bull. 1994;20(2):287-96. doi: 10.1093/schbul/20.2.287.
Age at onset and sex differences in the age at onset were investigated in the schizophrenic subtypes of 200 patients. Significant differences in the age at onset were observed among these subtypes; the disorganized subtype demonstrated the earliest and the paranoid the latest onset. The mean age at onset of all female patients was significantly greater than that of the male. Specifically, in the paranoid subtype the onset for men occurred earlier than for women. Conversely, in the disorganized subtype the disorder appeared earlier in women. There was no significant sex difference in the age at onset in the undifferentiated and the residual subtypes. In the paranoid subtype most men developed the disease before age 30 (72%), whereas women had an even distribution of the onset before and after 30. Ninety-six patients admitted for the first time demonstrated findings similar to those of the total sample. The data provide additional information on the phenotypic expression of the subtypes of schizophrenic disorders and indicate the necessity for further demographic and genetic studies to delineate the underlying defect.
对200例精神分裂症患者的亚型进行了起病年龄及起病年龄的性别差异研究。在这些亚型中观察到起病年龄存在显著差异；紊乱型亚型起病最早，偏执型起病最晚。所有女性患者的平均起病年龄显著大于男性。具体而言，在偏执型亚型中，男性起病早于女性。相反，在紊乱型亚型中，该疾病在女性中出现得更早。未分化型和残留型亚型的起病年龄不存在显著性别差异。在偏执型亚型中，大多数男性在30岁之前发病（72%），而女性在30岁前后发病分布均匀。首次入院的96例患者表现出与总样本相似的结果。这些数据提供了关于精神分裂症亚型表型表达的更多信息，并表明有必要进行进一步的人口统计学和遗传学研究以明确潜在缺陷。
