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恩杂鲁胺用于生化复发前列腺癌:EMBARK研究的主要发现

Enzalutamide in biochemically recurrent prostate cancer: key findings from the EMBARK study.

作者信息

Shore Neal D, Woo Henry H

机构信息

Carolina Urologic Research Center, Myrtle Beach, SC, USA.

Department of Urology, Blacktown and Mount Druitt Hospitals, Blacktown, New South Wales, Australia.

出版信息

Future Oncol. 2025 Apr;21(10):1151-1156. doi: 10.1080/14796694.2025.2479331. Epub 2025 Mar 27.

Abstract

This podcast features two of the investigators from the international, randomized, phase 3 EMBARK trial (NCT02319837) in conversation. EMBARK evaluated the efficacy and safety of enzalutamide plus androgen deprivation therapy and enzalutamide monotherapy, as compared with androgen deprivation therapy alone, in patients with nonmetastatic castration-sensitive prostate cancer and biochemical recurrence at high risk for metastasis. In this podcast, the second in the EMBARK series, the speakers discuss the key efficacy and safety findings from the trial, consider some of the patient-reported outcomes and their implications for quality of life, and review some of the implications for clinical practice.

摘要

本期播客邀请了国际随机3期EMBARK试验(NCT02319837)的两位研究人员进行对话。EMBARK评估了恩杂鲁胺联合雄激素剥夺疗法以及恩杂鲁胺单药疗法,与单纯雄激素剥夺疗法相比,在非转移性去势敏感性前列腺癌且有高转移风险生化复发患者中的疗效和安全性。在本期播客中,作为EMBARK系列的第二期,嘉宾们讨论了该试验的关键疗效和安全性结果,探讨了一些患者报告的结局及其对生活质量的影响,并回顾了对临床实践的一些启示。

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