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胆固醇代谢及其调节在肿瘤发生中的作用。

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development.

作者信息

Wu Yongmei, Song Wenqian, Su Min, He Jing, Hu Rong, Zhao Youbo

机构信息

Department of Human Histology and Embryology, Guizhou Medical University, Guiyang, Guizhou, China.

Center for Tissue Engineering and Stem Cell Research, Key Laboratory of Regenerative Medicine in Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China.

出版信息

Cancer Med. 2025 Apr;14(7):e70783. doi: 10.1002/cam4.70783.

DOI:10.1002/cam4.70783
PMID:40145543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11948085/
Abstract

BACKGROUND

Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently promoting tumorigenesis. These biological changes involve modifications in numerous enzymes associated with cholesterol uptake and synthesis, including NPC1L1, SREBP, HMGCR, SQLE, and PCSK9.

REVIEW

This review systematically summarizes the role of cholesterol metabolism and its associated enzymes in cancer progression, examines the mechanisms through which dysregulation of cholesterol metabolism affects immune cells within the tumor microenvironment, and discusses recent advancements in cancer therapies that target cholesterol metabolism.

CONCLUSION

Targeting cholesterol metabolism-related enzymes can inhibit tumor growth, reshape immune landscapes, and rejuvenate antitumor immunity, offering potential therapeutic avenues in cancer treatment.

摘要

背景

在肿瘤微环境中，由于内在细胞改变和细胞外环境变化，肿瘤细胞会经历胆固醇的代谢重编程。此外，这种微环境中的胆固醇重编程会影响肿瘤的免疫格局，促进免疫逃逸，从而促进肿瘤发生。这些生物学变化涉及与胆固醇摄取和合成相关的多种酶的修饰，包括NPC1L1、SREBP、HMGCR、SQLE和PCSK9。

综述

本综述系统总结了胆固醇代谢及其相关酶在癌症进展中的作用，研究了胆固醇代谢失调影响肿瘤微环境中免疫细胞的机制，并讨论了靶向胆固醇代谢的癌症治疗的最新进展。

结论

靶向胆固醇代谢相关酶可抑制肿瘤生长、重塑免疫格局并恢复抗肿瘤免疫力，为癌症治疗提供了潜在的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/972dbdc1fdca/CAM4-14-e70783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/d9be04db60ad/CAM4-14-e70783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/72e167d3f86b/CAM4-14-e70783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/896a6386ed83/CAM4-14-e70783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/488d0703d332/CAM4-14-e70783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/972dbdc1fdca/CAM4-14-e70783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/d9be04db60ad/CAM4-14-e70783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/72e167d3f86b/CAM4-14-e70783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/896a6386ed83/CAM4-14-e70783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/488d0703d332/CAM4-14-e70783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e1/11948085/972dbdc1fdca/CAM4-14-e70783-g001.jpg

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