Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P.R, 100023, China.
Key Laboratory of Research in Pancreatic Tumor, Chinese Academy of Medical Sciences, Beijing, 100023, P.R, China.
Cell Commun Signal. 2024 Jul 29;22(1):380. doi: 10.1186/s12964-024-01760-1.
Amino acid metabolism plays a pivotal role in tumor microenvironment, influencing various aspects of cancer progression. The metabolic reprogramming of amino acids in tumor cells is intricately linked to protein synthesis, nucleotide synthesis, modulation of signaling pathways, regulation of tumor cell metabolism, maintenance of oxidative stress homeostasis, and epigenetic modifications. Furthermore, the dysregulation of amino acid metabolism also impacts tumor microenvironment and tumor immunity. Amino acids can act as signaling molecules that modulate immune cell function and immune tolerance within the tumor microenvironment, reshaping the anti-tumor immune response and promoting immune evasion by cancer cells. Moreover, amino acid metabolism can influence the behavior of stromal cells, such as cancer-associated fibroblasts, regulate ECM remodeling and promote angiogenesis, thereby facilitating tumor growth and metastasis. Understanding the intricate interplay between amino acid metabolism and the tumor microenvironment is of crucial significance. Expanding our knowledge of the multifaceted roles of amino acid metabolism in tumor microenvironment holds significant promise for the development of more effective cancer therapies aimed at disrupting the metabolic dependencies of cancer cells and modulating the tumor microenvironment to enhance anti-tumor immune responses and inhibit tumor progression.
氨基酸代谢在肿瘤微环境中起着关键作用，影响着癌症进展的各个方面。肿瘤细胞中氨基酸的代谢重编程与蛋白质合成、核苷酸合成、信号通路的调节、肿瘤细胞代谢的调节、氧化应激平衡的维持以及表观遗传修饰密切相关。此外，氨基酸代谢的失调也会影响肿瘤微环境和肿瘤免疫。氨基酸可以作为信号分子，调节肿瘤微环境中免疫细胞的功能和免疫耐受，重塑抗肿瘤免疫反应，并促进癌细胞的免疫逃逸。此外，氨基酸代谢还可以影响基质细胞（如肿瘤相关成纤维细胞）的行为，调节细胞外基质的重塑和促进血管生成，从而促进肿瘤的生长和转移。了解氨基酸代谢与肿瘤微环境之间的复杂相互作用至关重要。深入了解氨基酸代谢在肿瘤微环境中的多方面作用，有望开发出更有效的癌症治疗方法，旨在破坏癌细胞的代谢依赖性，并调节肿瘤微环境，以增强抗肿瘤免疫反应和抑制肿瘤进展。
