Robinson E P, Rex M A, Brown T C
Anaesth Intensive Care. 1985 May;13(2):137-44. doi: 10.1177/0310057X8501300205.
Electromyographic (EMG) recordings were made from the intrinsic laryngeal muscles (cricothyroid, thyroarytenoid) and the diaphragm of the cat to compare the effect of the same dose of different concentrations of lignocaine hydrocholoride applied topically to the laryngeal mucosa. All concentrations of lignocaine hydrochloride tested, two, five and ten per cent, produced desensitisation of the larynx, as demonstrated by a loss of response of the crocothyroid and thyroarytenoid to mechanical stimulation of the mucosa. Desensitisation was produced in a mean of 1.80 minutes in the thirty experiments performed. Return of baseline response took significantly longer when 5 or 10% lignocaine was used compared with that when 2% was used (p less than 0.05). The usefulness of lignocaine hydrochloride as a topical anaesthetic for the larynx is reviewed.
从猫的喉内肌（环甲肌、甲杓肌）和膈肌进行肌电图（EMG）记录，以比较相同剂量不同浓度的盐酸利多卡因局部应用于喉黏膜的效果。所测试的所有盐酸利多卡因浓度，即2%、5%和10%，均产生了喉部脱敏作用，这通过环甲肌和甲杓肌对黏膜机械刺激的反应丧失得以证明。在进行的30项实验中，平均1.80分钟产生脱敏作用。与使用2%利多卡因相比，使用5%或10%利多卡因时基线反应恢复所需时间显著更长（p小于0.05）。本文综述了盐酸利多卡因作为喉部局部麻醉剂的效用。
