Wang Leihan, Qi Teng, Tang Lingyun, Wang Yuehan, ChenLiu Zhenni, Wang Daorong, Tang Dong
Clinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Department of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Northern Jiangsu People's Hospital Yangzhou, Yangzhou, 225000, China.
Mol Cell Biochem. 2025 Mar 27. doi: 10.1007/s11010-025-05256-5.
The nervous system, which regulates organogenesis, homeostasis, and plasticity of the organism during human growth and development, integrates physiological functions of all organ systems, including the immune system. Its extensive network of branches throughout the body reaches the tumor microenvironment (TME), where it secretes neurotransmitters that directly regulate or influence immune cells. This, in turn, indirectly affects the occurrence, development, and metastasis of cancer. Conversely, cancer cells are now understood to secrete neurotrophic factors that remodel the nervous system. Targeting the cross-talk between the nervous system and cancer represents a promising strategy for cancer treatment, some aspects of which have been confirmed in clinical trials. This review addresses gaps in our understanding of the interaction between peripheral nerves and various human cancers. At the intersection of neuroscience and cancer biology, new targets for neuroscience-based cancer therapies are emerging, establishing a significant new pillar in cancer treatment.
神经系统在人类生长发育过程中调节机体的器官发生、体内平衡和可塑性，整合包括免疫系统在内的所有器官系统的生理功能。其遍布全身的广泛分支网络延伸至肿瘤微环境（TME），在那里它分泌直接调节或影响免疫细胞的神经递质。这反过来又间接影响癌症的发生、发展和转移。相反，现在已知癌细胞会分泌神经营养因子来重塑神经系统。针对神经系统与癌症之间的相互作用是一种很有前景的癌症治疗策略，其中一些方面已在临床试验中得到证实。本综述阐述了我们在理解外周神经与各种人类癌症之间相互作用方面的差距。在神经科学与癌症生物学的交叉点上，基于神经科学的癌症治疗新靶点正在出现，为癌症治疗建立了一个重要的新支柱。
