Rohilla Rachna, Gupta Mayank, Anish Thekkumkara Surendran, Cherian Jerin Jose, Singh Mahendra Pratap, Kakkar Ashish Kumar, Mukherjee Aparna, Mittal Niti, Kaushal Sandeep, Vijay Devi, Kaushik Robin, Naeem Syed Shariq, Charan Jaykaran
Department of Pharmacology, All India Institute of Medical Sciences (AIIMS) Bathinda, Bathinda, Punjab, India.
Department of Anaesthesiology, All India Institute of Medical Sciences (AIIMS) Bathinda, Bathinda, Punjab, India.
PLoS One. 2025 Mar 27;20(3):e0319645. doi: 10.1371/journal.pone.0319645. eCollection 2025.
Surgical site infections (SSIs) are a major yet preventable cause of poor post-operative clinical outcomes, prolonged ICU/hospital stay, increased antibiotic consumption and added cost of therapy. Low- and Middle-income Countries (LMICs) have disproportionately higher rates of SSIs as compared to high-income countries despite various national and international guidelines in place as multipronged, combined interventions are seldom used. The IMPRESS project aims to respond to this urgent need to identify and evaluate the quality improvement measures contextualized to the logistic constraints of LMIC settings such as India.
We adopt a multi-center longitudinal mixed-methods study to be conducted over a period of 2 years in various phases. Phase 1 will be formative research with the objective of identifying knowledge gaps and baseline data collection. Phase II will involve co-development of multipronged interventions addressing identified barriers. Phase III will focus on the deployment of the selected multipronged interventions. Phase IV will be the post-intervention phase to evaluate the impact of the interventions. The study has been prospectively registered with CTRI and is supported by a funding grant from the Indian Council of Medical Research, New Delhi. The Institutional Ethics Committee approval has been obtained from all the sites involved in the study.
手术部位感染（SSIs）是导致术后临床预后不良、重症监护病房/住院时间延长、抗生素使用增加及治疗费用上升的一个主要但可预防的原因。尽管有各种国家和国际指南，但与高收入国家相比，低收入和中等收入国家（LMICs）的手术部位感染发生率仍然高得多，因为很少采用多管齐下的联合干预措施。IMPRESS项目旨在满足这一迫切需求，即确定和评估针对印度等LMICs地区后勤限制情况的质量改进措施。
我们采用多中心纵向混合方法研究，分多个阶段进行，为期2年。第一阶段将进行形成性研究，目的是识别知识差距并收集基线数据。第二阶段将共同制定针对已识别障碍的多管齐下干预措施。第三阶段将专注于选定的多管齐下干预措施的部署。第四阶段将是干预后阶段，以评估干预措施的影响。该研究已在印度临床试验注册中心（CTRI）进行前瞻性注册，并得到新德里印度医学研究理事会的资助。已获得参与研究的所有机构的伦理委员会批准。
