Gan Lizhen, Chen Pei, Zhang Zhi, He Xinyi, Wu Xia, Chen Zhewei, Wei Qingbo, Wu Yunchuan
School of Acupuncture-Moxibustion and Tuina, and School of Health Preservation and Rehabilitation, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, 999078, China.
Sci Rep. 2025 Mar 27;15(1):10662. doi: 10.1038/s41598-025-94360-z.
Type 2 diabetes mellitus (T2DM) is a condition marked by insulin resistance and hyperglycemia. Static training, as a form of exercise intervention, is increasingly demonstrating benefits for improving T2DM. However, the underlying mechanisms remain inadequately elucidated. Research suggests that insulin-like growth factor 2 (IGF-2) could be a significant contributor to this phenomenon. In this study, static training significantly reduced fasting and random blood glucose, total cholesterol, triglycerides, and LDL, while increasing HDL and improving insulin sensitivity. Transcriptomics suggested that static training might regulate the IGF-2 pathway and related genes. WB and PCR results showed that IGF-2 expression was upregulated in the static training group, and IGF-2 inhibitors attenuated these effects, whereas IGF-2 overexpression enhanced them. In conclusion, static training improves insulin resistance in T2DM mice via the IGF-2/IGF-1R pathway, suggesting its potential as a therapeutic intervention.
2型糖尿病（T2DM）是一种以胰岛素抵抗和高血糖为特征的疾病。静态训练作为一种运动干预形式，在改善T2DM方面越来越显示出益处。然而，其潜在机制仍未得到充分阐明。研究表明，胰岛素样生长因子2（IGF-2）可能是这一现象的重要促成因素。在本研究中，静态训练显著降低了空腹血糖和随机血糖、总胆固醇、甘油三酯和低密度脂蛋白，同时提高了高密度脂蛋白并改善了胰岛素敏感性。转录组学表明，静态训练可能调节IGF-2通路及相关基因。蛋白质免疫印迹（WB）和聚合酶链反应（PCR）结果显示，静态训练组中IGF-2表达上调，IGF-2抑制剂减弱了这些作用，而IGF-2过表达增强了这些作用。总之，静态训练通过IGF-2/IGF-1R通路改善T2DM小鼠的胰岛素抵抗，表明其作为一种治疗干预手段的潜力。
