Mitochondrial Genome Analysis of (Apicomplexa: Babesiidae) Endemic in Sheep in Türkiye.

This study presents the first comprehensive analysis of the mitochondrial genome of , a significant pathogen in ovine babesiosis in Türkiye. The mitochondrial genome is a linear monomeric molecule of 6015 bp with an A + T content of 70.5%, featuring terminal inverted repeats (TIRs) at both ends. It encodes three essential proteins (Cox1, Cox3, and Cob) and six fragments of genes. Comparative analysis revealed high sequence identity with sp. Xinjiang (87.5%) and sp. Dunhuang (87.5%), suggesting a close evolutionary relationship. The study highlights the conservation of mitochondrial gene content across and species, emphasizing their utility in phylogenetic studies. The findings also suggest that TIR variability plays a role in mitochondrial genome size differences, influencing species-specific adaptations. This research provides valuable insights into the evolution and functional adaptations of and underscores the potential of mitochondrial genomic data in enhancing diagnostic and therapeutic strategies for babesiosis. Further exploration of mitochondrial genomes in species is essential for understanding their biology and developing effective control measures.