因去甲替林中毒出现严重神经和心血管表现的患者经脂质乳剂和血浆置换治疗后获得成功结局：一例报告
Successful outcome following intralipid emulsion and plasmapheresis in a patient with profound neurologic and cardiovascular manifestations due to nortriptyline poisoning: a case report.
作者信息
Ahmadinejad Asma, Saeed Amir, Davoodi Marzieh
机构信息
Department of Pediatrics, Division of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pediatrics, Division of Pediatric Intensive Care, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Int J Emerg Med. 2025 Mar 27;18(1):61. doi: 10.1186/s12245-025-00824-4.
OBJECTIVE
Tricyclic antidepressants (TCAs) are used to treat depression, but if abused or misused, they can cause poisoning, which can be fatal. The main treatment for TCA poisoning is administering sodium bicarbonate.
METHODS
We report a 16-year-old girl diagnosed with nortriptyline poisoning with a profound neurologic and cardiovascular manifestations, successfully treated using sodium bicarbonate, intralipid emulsion, and plasmapheresis.
CONCLUSIONS
Plasmapheresis can be a good treatment modality for patients with TCA poisoning who do not respond well to classic treatments.
目的
三环类抗抑郁药（TCAs）用于治疗抑郁症，但如果滥用或误用，会导致中毒，甚至可能致命。三环类抗抑郁药中毒的主要治疗方法是给予碳酸氢钠。
方法
我们报告一名16岁女孩被诊断为去甲替林中毒，伴有严重的神经和心血管表现，通过使用碳酸氢钠、脂质乳剂和血浆置换成功治愈。
结论
对于对传统治疗反应不佳的三环类抗抑郁药中毒患者，血浆置换可能是一种有效的治疗方式。
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