• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

因去甲替林中毒出现严重神经和心血管表现的患者经脂质乳剂和血浆置换治疗后获得成功结局：一例报告

Successful outcome following intralipid emulsion and plasmapheresis in a patient with profound neurologic and cardiovascular manifestations due to nortriptyline poisoning: a case report.

作者信息

Ahmadinejad Asma, Saeed Amir, Davoodi Marzieh

机构信息

Department of Pediatrics, Division of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Pediatrics, Division of Pediatric Intensive Care, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Int J Emerg Med. 2025 Mar 27;18(1):61. doi: 10.1186/s12245-025-00824-4.

DOI:10.1186/s12245-025-00824-4
PMID:40148818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11951764/
Abstract

OBJECTIVE

Tricyclic antidepressants (TCAs) are used to treat depression, but if abused or misused, they can cause poisoning, which can be fatal. The main treatment for TCA poisoning is administering sodium bicarbonate.

METHODS

We report a 16-year-old girl diagnosed with nortriptyline poisoning with a profound neurologic and cardiovascular manifestations, successfully treated using sodium bicarbonate, intralipid emulsion, and plasmapheresis.

CONCLUSIONS

Plasmapheresis can be a good treatment modality for patients with TCA poisoning who do not respond well to classic treatments.

摘要

目的

三环类抗抑郁药（TCAs）用于治疗抑郁症，但如果滥用或误用，会导致中毒，甚至可能致命。三环类抗抑郁药中毒的主要治疗方法是给予碳酸氢钠。

方法

我们报告一名16岁女孩被诊断为去甲替林中毒，伴有严重的神经和心血管表现，通过使用碳酸氢钠、脂质乳剂和血浆置换成功治愈。

结论

对于对传统治疗反应不佳的三环类抗抑郁药中毒患者，血浆置换可能是一种有效的治疗方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee7/11951764/b9f0f35110a3/12245_2025_824_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee7/11951764/8b1b5f70e256/12245_2025_824_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee7/11951764/b9f0f35110a3/12245_2025_824_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee7/11951764/8b1b5f70e256/12245_2025_824_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ee7/11951764/b9f0f35110a3/12245_2025_824_Fig2_HTML.jpg

相似文献

1
Successful outcome following intralipid emulsion and plasmapheresis in a patient with profound neurologic and cardiovascular manifestations due to nortriptyline poisoning: a case report.因去甲替林中毒出现严重神经和心血管表现的患者经脂质乳剂和血浆置换治疗后获得成功结局：一例报告
Int J Emerg Med. 2025 Mar 27;18(1):61. doi: 10.1186/s12245-025-00824-4.
2
Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management.三环类抗抑郁药中毒：院外管理的循证共识指南
Clin Toxicol (Phila). 2007;45(3):203-33. doi: 10.1080/15563650701226192.
3
Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016-2020.2016 - 2020年英格兰和威尔士三环类抗抑郁药的处方及中毒趋势
Br J Clin Pharmacol. 2025 Jun;91(6):1727-1738. doi: 10.1111/bcp.16400. Epub 2025 Jan 29.
4
Tricyclic antidepressant overdose treated with adjunctive lipid rescue and plasmapheresis.采用辅助性脂质救援和血浆置换治疗三环类抗抑郁药过量。
Proc (Bayl Univ Med Cent). 2016 Jul;29(3):284-7. doi: 10.1080/08998280.2016.11929437.
5
[How I treat … a poisoning with tricyclic antidepressants : potential role of a treatment with lipid emulsion].[我如何治疗……三环类抗抑郁药中毒：脂质乳剂治疗的潜在作用]
Rev Med Liege. 2017 Jan;72(1):6-9.
6
Superior Efficacy of Lipid Emulsion Infusion Over Serum Alkalinization in Reversing Amitriptyline-Induced Cardiotoxicity in Guinea Pig.脂质乳剂输注逆转曲马多诱导豚鼠心脏毒性的疗效优于血清碱化。
Anesth Analg. 2018 Apr;126(4):1159-1169. doi: 10.1213/ANE.0000000000002707.
7
Myofascial pain: an open study on the pharmacotherapeutic response to stepped treatment with tricyclic antidepressants and gabapentin.肌筋膜疼痛：三环类抗抑郁药和加巴喷丁阶梯治疗药物反应的开放性研究。
J Oral Facial Pain Headache. 2015 Spring;29(2):144-51. doi: 10.11607/ofph.1408.
8
Arterial blood gas analysis and the outcome of treatment in tricyclic antidepressants poisoned patients with benzodiazepine coingestion.三环类抗抑郁药中毒合并苯二氮䓬类药物摄入患者的动脉血气分析及治疗结果
Anesthesiol Res Pract. 2015;2015:232401. doi: 10.1155/2015/232401. Epub 2015 Jan 8.
9
Comparison of Clinical Manifestations of Patients Poisoned with Tricyclic Antidepressants Alone or with Benzodiazepine Intoxication According to the Dose of Benzodiazepines.根据苯二氮䓬类药物剂量比较单独服用三环类抗抑郁药中毒或合并苯二氮䓬类药物中毒患者的临床表现
J Res Pharm Pract. 2022 Dec 14;11(2):59-63. doi: 10.4103/jrpp.jrpp_43_21. eCollection 2022 Apr-Jun.
10
Intravenous lipid emulsion therapy does not improve hypotension compared to sodium bicarbonate for tricyclic antidepressant toxicity: a randomized, controlled pilot study in a swine model.在猪模型中进行的一项随机对照试验性研究表明，对于三环类抗抑郁药中毒，与碳酸氢钠相比，静脉注射脂质乳剂疗法并不能改善低血压症状。
Acad Emerg Med. 2014 Nov;21(11):1212-9. doi: 10.1111/acem.12513.

本文引用的文献

1
The Occasional intralipid emulsion therapy.间歇性脂肪乳剂疗法。
Can J Rural Med. 2023 Oct-Dec;28(4):195-200. doi: 10.4103/cjrm.cjrm_62_22.
2
Use of Iatrogenic Lipid Emulsion and Subsequent Plasmapheresis for the Treatment of Amitriptyline Overdose.使用医源性脂质乳剂及随后的血浆置换治疗阿米替林过量
Case Rep Crit Care. 2022 Oct 5;2022:1090795. doi: 10.1155/2022/1090795. eCollection 2022.
3
Successful Outcome Following Intravenous Lipid Emulsion Rescue Therapy in a Patient with Cardiac Arrest Due to Amitriptyline Overdose.
静脉注射脂肪乳剂抢救治疗曲马多过量致心脏骤停患者成功。
Am J Case Rep. 2020 May 24;21:e922206. doi: 10.12659/AJCR.922206.
4
Lipid therapy and plasmapheresis in tricyclic poisoning.三环类中毒的脂质疗法和血浆置换
Proc (Bayl Univ Med Cent). 2016 Oct;29(4):444-445.
5
Tricyclic antidepressant overdose treated with adjunctive lipid rescue and plasmapheresis.采用辅助性脂质救援和血浆置换治疗三环类抗抑郁药过量。
Proc (Bayl Univ Med Cent). 2016 Jul;29(3):284-7. doi: 10.1080/08998280.2016.11929437.
6
Extracorporeal treatment for tricyclic antidepressant poisoning: recommendations from the EXTRIP Workgroup.三环类抗抑郁药中毒的体外治疗：EXTRIP工作组的建议
Semin Dial. 2014 Jul-Aug;27(4):381-9. doi: 10.1111/sdi.12227. Epub 2014 Apr 9.
7
Amitriptyline overdose in emergency department of university hospital: evaluation of 250 patients.大学医院急诊科三环类抗抑郁药阿米替林过量中毒：250例患者的评估
Hum Exp Toxicol. 2014 Sep;33(9):980-90. doi: 10.1177/0960327113520019. Epub 2014 Feb 6.
8
Antidepressants medications and the relative risk of suicide attempt.抗抑郁药物与自杀未遂的相对风险。
Toxicol Int. 2012 Jan;19(1):42-6. doi: 10.4103/0971-6580.94517.
9
Therapeutic plasma exchange in amitriptyline intoxication: case report and review of the literature.阿米替林中毒的治疗性血浆置换：病例报告及文献综述
Transfus Apher Sci. 2011 Oct;45(2):183-5. doi: 10.1016/j.transci.2011.07.015. Epub 2011 Aug 26.
10
Guidelines in Emergency Medicine Network (GEMNet): guideline for the management of tricyclic antidepressant overdose.急危重症网络指南（GEMNet）：三环类抗抑郁药过量管理指南。
Emerg Med J. 2011 Apr;28(4):347-68. doi: 10.1136/emj.2010.091553.