Ks Sneha, Natarajan Srikant, Boaz Karen, Baliga Shrikala, Ramapuram John, Solomon Monica Charlotte, Manaktala Nidhi, Chitra Nunna Sai
Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Microbiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.
BMC Res Notes. 2025 Mar 27;18(1):130. doi: 10.1186/s13104-025-07190-7.
Candidiasis, an opportunistic infection that is prevalent in HIV-positive children and adults, is caused by various Candida species, Candida albicans along with certain non-albicans Candida species. The prevalence of these species varies across age groups due to multiple factors. Identification of these species becomes necessary as any antifungal therapy requires species-specific targeting to manage candidiasis effectively. With this background, the present study aimed to evaluate the prevalence and speciation of Candida in HIV-positive children (n = 30) and adults (n = 40) and to compare these findings with those in healthy individuals. Ten mL saliva was collected from HIV-positive and HIV-negative (healthy) patients and cultured on CHROMAgar™.
The proportion and quantity of candidal colonization was higher in HIV-positive children (93.30%) as compared to adults (67.50%). An increased profile of Nakaseomyces glabrata (previously Candida glabrata) was seen in children while the adults showed increase in colonization of C. tropicalis. The shift in profiles of species from Candida albicans to 'non-albicans' Candida species is of clinical relevance as it directly impacts on the antimicrobial efficacy of chosen anti-fungal agents.
念珠菌病是一种在艾滋病毒阳性儿童和成人中普遍存在的机会性感染，由多种念珠菌引起，包括白色念珠菌以及某些非白色念珠菌。由于多种因素，这些念珠菌物种的患病率在不同年龄组中有所不同。由于任何抗真菌治疗都需要针对特定物种进行靶向治疗以有效控制念珠菌病，因此对这些物种进行鉴定变得必要。在此背景下，本研究旨在评估艾滋病毒阳性儿童（n = 30）和成人（n = 40）中念珠菌的患病率和种类，并将这些结果与健康个体的结果进行比较。从艾滋病毒阳性和艾滋病毒阴性（健康）患者中收集10毫升唾液，并在科玛嘉显色培养基上进行培养。
与成人（67.50%）相比，艾滋病毒阳性儿童的念珠菌定植比例和数量更高（93.30%）。在儿童中，光滑假丝酵母菌（以前称为光滑念珠菌）的比例增加，而在成人中，热带念珠菌的定植增加。念珠菌种类从白色念珠菌向“非白色念珠菌”的转变具有临床意义，因为它直接影响所选抗真菌药物的抗菌效果。
