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睡眠障碍与心血管疾病之间的相互作用:一项系统综述

The Interplay Between Sleep Disorders and Cardiovascular Diseases: A Systematic Review.

作者信息

Ravichandran Rakshana, Gupta Lovish, Singh Mansi, Nag Aiswarya, Thomas Jingle, Panjiyar Binay K

机构信息

Department of Internal Medicine, Rajarajeswari Medical College and Hospital, Bangalore, IND.

Department of Internal Medicine, Maulana Azad Medical College, New Delhi, IND.

出版信息

Cureus. 2023 Sep 25;15(9):e45898. doi: 10.7759/cureus.45898. eCollection 2023 Sep.

Abstract

Non-communicable diseases (NCDs) have emerged as the predominant cause of global mortality, resulting in a substantial annual loss of human lives. Among these conditions, cardiovascular diseases (CVD) stand out as the primary cause of death. The majority of CVD cases can be attributed to certain factors that, upon modification, have the potential to significantly decrease both the incidence and severity of the disease. For numerous years, the impact of sleep disorders on cardiovascular health has been a prominent subject of extensive discussion. Chronic sleep disturbances are known to have a range of negative health consequences, with the relationship between sleep apnea and hypertension being well-established through numerous studies. However, further exploration is needed to understand other disease associations with sleep apnea and to examine the impact of various sleep disorders, aside from sleep apnea, on cardiovascular health. This systematic review assesses the available evidence on the association between various sleep disorders and cardiovascular diseases by addressing the question: Do sleep disorders contribute to or exacerbate cardiovascular diseases? After a comprehensive review, we identified 122 articles. Following this initial review, seven papers directly aligned with our research topic. Subsequently, we meticulously assessed the remaining seven papers, all meeting our predetermined criteria. Our analysis showed a strong correlation between sleep disruptions and cardiovascular health. Numerous sleep disorders, such as narcolepsy, central sleep apnea, obstructive sleep apnea, and insomnia, have shown different effects on cardiovascular outcomes. Increased risks of illnesses such as acute coronary syndrome (ACS), hypertension, cardiovascular mortality, and coronary artery calcification were included in these consequences. This systematic review underscores the need for early identification and comprehensive management of sleep disturbances to mitigate their potential adverse effects on cardiovascular well-being. Integrating strategies that address sleep disorders and cardiovascular health is imperative in enhancing overall health outcomes. This study paves the way for more effective preventive and therapeutic approaches by focusing on the relationship between sleep disorders and cardiovascular diseases.

摘要

非传染性疾病(NCDs)已成为全球死亡的主要原因,每年导致大量人员生命损失。在这些疾病中,心血管疾病(CVD)是主要死因。大多数心血管疾病病例可归因于某些因素,改变这些因素有可能显著降低疾病的发病率和严重程度。多年来,睡眠障碍对心血管健康的影响一直是广泛讨论的突出话题。众所周知,慢性睡眠干扰会对健康产生一系列负面影响,通过大量研究已充分证实睡眠呼吸暂停与高血压之间的关系。然而,还需要进一步探索以了解其他与睡眠呼吸暂停相关的疾病关联,并研究除睡眠呼吸暂停外的各种睡眠障碍对心血管健康的影响。本系统评价通过解决以下问题来评估各种睡眠障碍与心血管疾病之间关联的现有证据:睡眠障碍是否会导致或加重心血管疾病?经过全面审查,我们确定了122篇文章。在初步审查之后,有七篇论文与我们的研究主题直接相关。随后,我们仔细评估了其余七篇论文,所有这些论文均符合我们预先设定的标准。我们的分析表明睡眠中断与心血管健康之间存在密切关联。多种睡眠障碍,如发作性睡病、中枢性睡眠呼吸暂停、阻塞性睡眠呼吸暂停和失眠,对心血管结局表现出不同的影响。这些后果包括急性冠状动脉综合征(ACS)、高血压、心血管死亡率和冠状动脉钙化等疾病风险增加。本系统评价强调需要早期识别和全面管理睡眠干扰,以减轻其对心血管健康的潜在不利影响。整合解决睡眠障碍和心血管健康问题的策略对于提高整体健康结局至关重要。本研究通过关注睡眠障碍与心血管疾病之间的关系,为更有效的预防和治疗方法铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beda/10598613/bb6789335bd9/cureus-0015-00000045898-i01.jpg

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