Chen Yung-Tai, Lee Hsiang-Ying, Wu Wen-Jeng, Lin Chih-Hung, Jiang Yuan-Hong, Lee Yu-Khun, Huang Kuan-Hsun, Tsai Yao-Chou
Department of Urology, Taiwan Adventist Hospital, Taipei 10556, Taiwan.
Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Cancers (Basel). 2025 Mar 8;17(6):923. doi: 10.3390/cancers17060923.
Existing T3 subclassifications for upper tract urothelial cancer (UTUC) are limited by heterogeneity and a primary focus on renal pelvis tumors. Our study aimed to propose a novel pT3 subclassification system specifically tailored to pT3 UTUC patients. This study analyzed 120 pT3 UTUC cases from a Taiwanese multicenter registry, using a standardized pathology report and a single pathologist for evaluation. Univariate analysis revealed survival differences based on existing subclassifications. Multivariate analysis identified concurrent fat and parenchyma invasion as an independent predictor of worse overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). : This study proposes a novel pT3 subclassification incorporating fat and parenchyma invasion, applicable to all UTUC sites. This subclassification may improve risk stratification, guide treatment decisions, and ultimately enhance patient outcomes.
上尿路尿路上皮癌（UTUC）现有的T3亚分类受异质性限制，且主要聚焦于肾盂肿瘤。我们的研究旨在提出一种专门为pT3 UTUC患者量身定制的新型pT3亚分类系统。本研究分析了来自台湾多中心登记处的120例pT3 UTUC病例，使用标准化病理报告并由单一病理学家进行评估。单因素分析显示基于现有亚分类存在生存差异。多因素分析确定同时存在脂肪和实质侵犯是总体生存（OS）、癌症特异性生存（CSS）和无病生存（DFS）较差的独立预测因素。本研究提出了一种纳入脂肪和实质侵犯的新型pT3亚分类，适用于所有UTUC部位。这种亚分类可能改善风险分层，指导治疗决策，并最终提高患者预后。
