Ko Li-Chuan, Gravina Nick, Berghausen Joos, Abdo Joe
Department of Biochemistry, Molecular & Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA.
AstraZeneca, 1 Medimmune Way, Gaithersburg, MD 20878, USA.
Cancers (Basel). 2025 Mar 17;17(6):1013. doi: 10.3390/cancers17061013.
Asia comprises 60% of the global male population, yet Asian men's health issues, such as prostate cancer, remain sparse in the literature. Clinical researchers have often overlooked prostate cancer in Asian men, as available statistics suggest that Asian men are less likely to develop prostate cancer compared to Caucasian, Black, and Hispanic males. However, cultural investigations have indicated these figures may be influenced by factors such as cultural taboos, superstition and misconception, limited access to diagnostic tools and healthcare facilities, and epidemiological factors in terms of lifestyle, environmental exposure, and genetics. In particular, the lack of diagnostic resources, coupled with cultural stigmas surrounding cancers affecting the genitalia in Asian societies, may contribute to significant underreporting. Rapid aging population growth in East Asia and the continuing shift in Asiatic lifestyles towards Westernization will likely contribute to a continued rise in prostate cancer incidence among Asian men in the coming years. A comprehensive review of novel and commercially available prostate cancer detection tests demonstrates that accurate, less-invasive tools could relieve many of the pressures surrounding Asian men and their prostate health.
亚洲男性占全球男性人口的60%，然而，诸如前列腺癌等亚洲男性的健康问题在文献中仍然较少提及。临床研究人员常常忽视亚洲男性的前列腺癌，因为现有统计数据表明，与白种人、黑人和西班牙裔男性相比，亚洲男性患前列腺癌的可能性较小。然而，文化调查表明，这些数据可能受到多种因素的影响，如文化禁忌、迷信和误解、获得诊断工具和医疗设施的机会有限，以及生活方式、环境暴露和遗传方面的流行病学因素。特别是，缺乏诊断资源，再加上亚洲社会中围绕影响生殖器的癌症的文化耻辱感，可能导致报告不足的情况严重。东亚人口的快速老龄化以及亚洲生活方式持续向西方化转变，可能会导致未来几年亚洲男性前列腺癌发病率持续上升。对新型和商用前列腺癌检测测试的全面综述表明，准确、侵入性较小的工具可以缓解围绕亚洲男性及其前列腺健康的许多压力。
