Thamm Carla, Button Elise, Johal Jolyn, Knowles Reegan, Paterson Catherine, Halpern Michael T, Charalambous Andreas, Chan Alexandre, Aranda Sanchia, Taylor Carolyn, Chan Raymond J
Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia.
Cancer and Palliative Care Outcomes Center, School of Nursing, Queensland University of Technology, Brisbane, QLD 4059, Australia.
Cancers (Basel). 2025 Mar 18;17(6):1023. doi: 10.3390/cancers17061023.
: Comprehensive cancer centers (CCCs) remain at the forefront of cancer control efforts. Limited clarity and variation exist around the models, scope, characteristics, and impacts of CCCs around the globe. This scoping review systematically searched and synthesized the international literature, describing core attributes and anticipated and realized impacts of CCCs, detailing changes over time. : Searches for English language sources were conducted across PubMed, Cochrane CENTRAL, Epistemonikos, and the gray literature from January 2002 to April 2024. Data were extracted and appraised by two authors. Results were narratively synthesized. : Of 3895 database records and 843 gray literature sources screened, 81 sources were included. Papers were predominantly opinion-based, from the USA and Europe, and published between 2011 and 2020. Internationally, the interconnected attributes of CCCs included (1) clinical service provision; (2) research, data, and innovation; (3) education and clinical support; (4) networks and leadership; (5) health equity and inclusiveness; and (6) accountability and governance. Largely anticipated impacts were synergistic and included delivery of optimal, person-centered, complex care; development of a highly qualified cancer workforce; greater research activity and funding; effective, strategic alliances; and reduction in cancer-related inequalities. Limited evidence was found demonstrating measurable broad outcomes of CCCs. The early literature highlighted the establishment, development, and accreditation of CCCs. The ongoing literature has reflected the evolution of cancer care, key areas for growth, and limitations of CCCs. Recently, the CCC literature has increased exponentially and focused on the need for CCCs to drive networks and leadership to address health equity and inclusiveness. : Results suggest that CCCs are yet to reach their full potential, with future efforts ideally focusing on accountability, effective networking, and health equity at a local, national, and international level. CCCs must generate evidence of impact, and continue to evolve in line with contemporary healthcare, to fulfil their role in cancer control efforts.
综合性癌症中心（CCC）始终处于癌症防控工作的前沿。全球范围内，CCC的模式、范围、特征和影响存在一定的模糊性和差异。本综述系统检索并综合了国际文献，描述了CCC的核心属性、预期影响和实际影响，并详细阐述了随时间的变化。：于2002年1月至2024年4月在PubMed、Cochrane CENTRAL、Epistemonikos以及灰色文献中检索英文文献来源。由两位作者提取和评估数据。对结果进行叙述性综合。：在筛选的3895条数据库记录和843条灰色文献来源中，纳入了81条来源。论文主要基于观点，来自美国和欧洲，发表于2011年至2020年之间。在国际上，CCC的相互关联属性包括：（1）临床服务提供；（2）研究、数据与创新；（3）教育与临床支持；（4）网络与领导力；（5）健康公平与包容性；（6）问责制与治理。在很大程度上，预期影响具有协同性，包括提供最佳的、以患者为中心的综合护理；培养高素质的癌症专业人员队伍；开展更多的研究活动并获得更多资金；建立有效的战略联盟；以及减少与癌症相关的不平等现象。发现有限的证据表明CCC产生了可衡量的广泛成果。早期文献强调了CCC的建立、发展和认证。当前的文献反映了癌症护理的演变、增长的关键领域以及CCC的局限性。最近，关于CCC的文献呈指数级增长，并且关注CCC推动网络和领导力以解决健康公平与包容性问题的必要性。：结果表明，CCC尚未充分发挥其潜力，未来的努力最好聚焦于地方、国家和国际层面的问责制、有效网络建设和健康公平。CCC必须产生影响的证据，并继续随着当代医疗保健的发展而演变，以履行其在癌症防控工作中的职责。
