Grassi Angela, Rocca Maria Santa, Noventa Marco, Pozzato Gianantonio, Pozzato Alessandro, Scioscia Marco, Andrisani Alessandra, Pontrelli Giovanni, Foresta Carlo, De Toni Luca
Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy.
Department of Medicine, University of Padova, 35128 Padova, Italy.
Genes (Basel). 2025 Feb 27;16(3):290. doi: 10.3390/genes16030290.
The identification of methods to improve the endometrial receptivity (ER) is increasingly of interest. The effect of the electromagnetic field associated with Quantum Molecular Resonance (QMR) on ER was investigated here.
Ishikawa cells were used to evaluate the effects of QMR both on the expression of a group of genes involved in ER, i.e., , , , , and , and on cell toxicity. Endometrial samples were obtained from six patients during routine diagnostic procedures, four of which were subsequently used to assess the transcriptional response to QMR through microarray.
Compared to unexposed controls, a single exposure of Ishikawa cells to QMR for 20 min was associated with a significant and power-dependent up-regulation of all the selected ER-related genes up to 8 power units (PU). Repeated exposure to QMR, up to three consecutive days, showed a significant up-regulation of all the selected genes at power values of 4 PU, from day two onwards. Negligible cytotoxicity was observed. Gene set enrichment analysis, on microarray data of endometrial biopsies stimulated for three consecutive days at 4 PU, showed a significant enrichment of specific gene sets, related to the proteasome system, the cell adhesion, the glucocorticoid receptor, and cell cycle pathways.
Our results suggest a possible favorable impact of QMR on ER.
确定改善子宫内膜容受性（ER）的方法越来越受到关注。本文研究了与量子分子共振（QMR）相关的电磁场对ER的影响。
使用 Ishikawa 细胞评估 QMR 对一组参与 ER 的基因（即 、 、 、 和 ）表达以及细胞毒性的影响。在常规诊断程序中从六名患者获取子宫内膜样本，其中四名随后用于通过微阵列评估对 QMR 的转录反应。
与未暴露的对照组相比，Ishikawa 细胞单次暴露于 QMR 20 分钟与所有选定的 ER 相关基因在高达 8 功率单位（PU）时显著且与功率相关的上调有关。重复暴露于 QMR，连续三天，从第二天起在 4 PU 的功率值下所有选定基因均显示出显著上调。观察到的细胞毒性可忽略不计。对在 4 PU 连续刺激三天的子宫内膜活检微阵列数据进行基因集富集分析，显示与蛋白酶体系统、细胞粘附、糖皮质激素受体和细胞周期途径相关的特定基因集显著富集。
我们的结果表明 QMR 对 ER 可能有有利影响。
