Diao Huantong, Wu Xiaolong, Li Xiaoran, Liu Siheng, Shan Bingyang, Cheng Ye, Lu Jie, Tang Jie
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Department of Neurosurgery, China International Neuroscience Institute, Beijing 100053, China.
Biomedicines. 2025 Mar 7;13(3):657. doi: 10.3390/biomedicines13030657.
: The objective of this study is to explore the potential variations in metabolic activity across gliomas originating from distinct cortical regions, as assessed by O-(2-F-fluoroethyl)-L-tyrosine positron emission tomography (F-FET PET). Also, this study seeks to elucidate whether these metabolic disparities correlate with the molecular characteristics and clinical prognoses of the tumors. Specifically, this research aims to determine whether variations in F-FET PET uptake are indicative of underlying genetic or biochemical differences that could influence patients' outcomes. : The researchers retrospectively included 107 patients diagnosed with gliomas from neocortex and mesocortex, all of whom underwent hybrid PET/MR examinations, including F-FET PET and diffusion weighted imaging (DWI), prior to surgery. The mean and maximum tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC) values were calculated based on whole tumor volume segmentations. Comparisons of TBR, ADC values, and survival outcomes were performed to determine statistical differences between groups. : Among glioblastomas (GBMs, WHO grade 4) originating from the two cortical regions, there was a significant difference in the human Telomerase Reverse Transcriptase () promoter mutation rate, while no difference was observed in O-Methylguanine-DNA Methyltransferase () promoter methylation status. For WHO grade 3 gliomas, significant differences were found in the promoter mutation rate and the proportion of 1p/19q co-deletion between the two cortical regions, whereas no difference was noted in methylation status. For WHO grade 2 gliomas, no molecular phenotypic differences were observed between the two cortical regions. In terms of survival, only GBMs originating from the mesocortex demonstrated significantly longer survival compared to those from the neocortex, while no statistically significant differences were found in survival for the other two groups. : Gliomas originating from different cortical regions exhibit variations in metabolic activity, molecular phenotypes, and clinical outcomes.
本研究的目的是通过O-(2-氟乙基)-L-酪氨酸正电子发射断层扫描(F-FET PET)评估，探索源自不同皮质区域的胶质瘤之间代谢活性的潜在差异。此外，本研究旨在阐明这些代谢差异是否与肿瘤的分子特征和临床预后相关。具体而言，本研究旨在确定F-FET PET摄取的变化是否表明存在可能影响患者预后的潜在遗传或生化差异。研究人员回顾性纳入了107例诊断为源自新皮质和中皮质的胶质瘤的患者，所有患者在手术前均接受了PET/MR混合检查，包括F-FET PET和扩散加权成像(DWI)。基于整个肿瘤体积分割计算平均和最大肿瘤与背景比值(TBR)以及表观扩散系数(ADC)值。进行TBR、ADC值和生存结果的比较以确定组间的统计学差异。在源自两个皮质区域的胶质母细胞瘤(GBM，WHO 4级)中，人端粒酶逆转录酶()启动子突变率存在显著差异，而O-甲基鸟嘌呤-DNA甲基转移酶()启动子甲基化状态未观察到差异。对于WHO 3级胶质瘤，两个皮质区域之间在启动子突变率和1p/19q共缺失比例方面存在显著差异，而甲基化状态未观察到差异。对于WHO 2级胶质瘤，两个皮质区域之间未观察到分子表型差异。在生存方面，只有源自中皮质的GBM与源自新皮质的GBM相比显示出显著更长的生存期，而其他两组在生存方面未发现统计学显著差异。源自不同皮质区域的胶质瘤在代谢活性、分子表型和临床结果方面存在差异。
