Zhou He, Fan Zhenzhen, Da Yu, Liu Xiaoning, Wang Chen, Zhang Tiantian, Zhang Jiaqi, Wu Tong, Liang Jie
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
Biomedicines. 2025 Mar 10;13(3):677. doi: 10.3390/biomedicines13030677.
: Iron deficiency anemia (IDA) is a common type of anemia in children and pregnant women. The effects of iron deficiency on gut microbiota and metabolic profiles are not fully understood. Mendelian randomization (MR) analysis was conducted to explore associations among IDA, gut microbiota, and metabolites. MR analysis was conducted using computational methods, utilizing human genetic data. Data were obtained from genome-wide association studies (GWAS), with inverse-variance-weighted (IVW) as the primary method. Animal models evaluated the effects of IDA on gut microbiota and metabolic profiles. IVW analysis revealed significant associations between gut microbial taxa and IDA. The genus was protective (OR = 0.85, 95% CI: 0.77-0.93, = 0.001), while (OR = 1.12, 95% CI: 1.01-1.23, = 0.025) and family (OR = 1.16, 95% CI: 1.01-1.32, = 0.035) increased IDA risk. Glycine was protective (OR = 0.95, 95% CI: 0.91-0.99, = 0.011), whereas medium low density lipoprotein (LDL) phospholipids increased risk (OR = 1.07, 95% CI: 1.00-1.15, = 0.040). Animal models confirmed reduced , increased , and altered metabolites, including amino acids and phospholipids. IDA significantly impacts gut microbiota and metabolic profiles, offering insights for therapeutic strategies targeting microbiota and metabolism.
缺铁性贫血（IDA）是儿童和孕妇中常见的贫血类型。缺铁对肠道微生物群和代谢谱的影响尚未完全了解。进行了孟德尔随机化（MR）分析以探讨IDA、肠道微生物群和代谢物之间的关联。MR分析使用计算方法，利用人类遗传数据。数据来自全基因组关联研究（GWAS），以逆方差加权（IVW）作为主要方法。动物模型评估了IDA对肠道微生物群和代谢谱的影响。IVW分析揭示了肠道微生物分类群与IDA之间的显著关联。某属具有保护作用（OR = 0.85，95% CI：0.77 - 0.93，P = 0.001），而另一个属（OR = 1.12，95% CI：1.01 - 1.23，P = 0.025）和某科（OR = 1.16，95% CI：1.01 - 1.32，P = 0.035）增加了IDA风险。甘氨酸具有保护作用（OR = 0.95，95% CI：0.91 - 0.99，P = 0.011），而中低密度脂蛋白（LDL）磷脂增加了风险（OR = 1.07，95% CI：1.00 - 1.15，P = 0.040）。动物模型证实了某指标减少、某指标增加以及包括氨基酸和磷脂在内的代谢物发生改变。IDA显著影响肠道微生物群和代谢谱，为针对微生物群和代谢的治疗策略提供了见解。
