Delibaş Katı Şennur, Uçan Tokuç Firdevs Ezgi
Department of Neurology, University of Health Sciences, Antalya Training and Research Hospital, 07100 Antalya, Türkiye.
Brain Sci. 2025 Mar 20;15(3):323. doi: 10.3390/brainsci15030323.
: Predicting mortality in patients with acute ischemic stroke who need endovascular treatment (EVT) has previously been shown to be related to inflammation. In this study, we aimed to examine the effects of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hypersensitive C-reactive protein-to-albumin ratio (CAR) values on mortality and hemorrhagic transformation. : A total of 225 adult patients who underwent EVT between 2022 and 2024 were retrospectively analyzed. The presence of intracranial hemorrhage (ICH) after the procedure; good and poor clinical outcomes according to modified Rankin Scores; mortality status; and NLR, PLR, and CAR values were collected. : The average age of the patients was 66.95 ± 12.74 years, and 133 (59.1%) patients were male. Thirty-eight (30.4%) patients had symptomatic ICH. While 164 (72.9%) patients had a poor outcome, 80 (35.6%) patients died. There was a correlation between the NLR and PLR values and symptomatic ICH ( = 0.013, 0.009, respectively) in the univariate analysis, but this relationship was not found in the multivariate analyses (: 0.212 and : 0.459). No statistically significant relationship was observed between the CAR and symptomatic ICH and mortality ( = 0.784, 0.079, respectively). When the laboratory data were compared according to the mortality status, the NLR and PLR were observed to be statistically significantly higher in the patients with mortality ( < 0.001, 0.005, respectively) in univariate analyses. But, as a result, the NLR, PLR, and CAR were not associated with ICH and mortality according to the multivariable logistic regression analysis. : Our findings highlight the need to better understand the post-stroke immune response. Our study demonstrated that the NLR, PLR, and CAR were not associated with ICH and mortality according to the multivariable logistic regression analysis.
以往研究表明，预测需要血管内治疗（EVT）的急性缺血性卒中患者的死亡率与炎症有关。在本研究中，我们旨在探讨中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及超敏C反应蛋白与白蛋白比值（CAR）对死亡率和出血性转化的影响。
对2022年至2024年间接受EVT的225例成年患者进行回顾性分析。收集术后颅内出血（ICH）的情况；根据改良Rankin评分评估的良好和不良临床结局；死亡率状况；以及NLR、PLR和CAR值。
患者的平均年龄为66.95±12.74岁，133例（59.1%）为男性。38例（30.4%）患者出现症状性ICH。164例（72.9%）患者预后不良，80例（35.6%）患者死亡。单因素分析中，NLR和PLR值与症状性ICH相关（分别为 = 0.013、0.009），但多因素分析未发现这种关系（分别为：0.212和：0.459）。未观察到CAR与症状性ICH和死亡率之间存在统计学显著关系（分别为 = 0.784、0.079）。根据死亡率状况比较实验室数据时，单因素分析中观察到死亡患者的NLR和PLR在统计学上显著更高（分别为 < 0.001、0.005）。但结果显示，根据多变量逻辑回归分析，NLR、PLR和CAR与ICH和死亡率无关。
我们的研究结果凸显了更好地了解卒中后免疫反应的必要性。我们的研究表明，根据多变量逻辑回归分析，NLR、PLR和CAR与ICH和死亡率无关。
