Luffau G, Pery P, Carrat C
Ann Rech Vet. 1985;16(1):17-23.
Groups of very similar sheep (breed, sex, age, hemoglobin type, family) were immunised against H. contortus by repeated infections. Self-cure and immune reactions expelled parasites but some of them still remain in the gut of animals; they have been eliminated by dosage of anthelmintics. Animal were challenged; a discrepancy exists between numbers of eggs passed in each group (immune and dosed animals, immune and non-dosed animals and non-immune animals); the best fitting estimated equation on experimental values (or on moving average points) is used for statistical tests. Immunity vanishes partly (or totally) when animals have been dosed; a residual population of worms is thought to be responsible for immunity because of a permanent booster.
将非常相似的绵羊群体（品种、性别、年龄、血红蛋白类型、家族）通过反复感染针对捻转血矛线虫进行免疫。自愈和免疫反应会驱除寄生虫，但仍有一些寄生虫留在动物肠道内；通过使用驱虫药剂量将它们清除。对动物进行攻虫试验；每组排出的虫卵数量（免疫和给药动物、免疫和未给药动物以及非免疫动物）之间存在差异；使用对实验值（或移动平均点）的最佳拟合估计方程进行统计检验。当给动物给药时，免疫力会部分（或完全）消失；由于持续的增强作用，认为残留的蠕虫群体是产生免疫力的原因。
