Cx43的过表达：它是治疗心血管疾病的有效方法吗？
Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?
作者信息
Boengler Kerstin, Mantuano Beatrice, Toledano Shira, Binah Ofer, Schulz Rainer
机构信息
Institute of Physiology, Justus-Liebig University, 35392 Giessen, Germany.
Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, Italy.
出版信息
Biomolecules. 2025 Mar 4;15(3):370. doi: 10.3390/biom15030370.
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation. Through its localization within nuclei and mitochondria, Cx43 influences the function of the respective organelles. Several cardiovascular diseases such as heart failure, ischemia/reperfusion injury, hypertrophic cardiomyopathy and arrhythmias are characterized by Cx43 downregulation and a dysregulated Cx43 function. Accordingly, a putative therapeutic approach of these diseases would include the induction of Cx43 expression in the damaged heart, albeit such induction may have both beneficial and detrimental effects. In this review we discuss the consequences of increasing cardiac Cx43 expression, and discuss this manipulation as a strategy for the treatment of cardiovascular diseases.
在心脏中，连接蛋白43（Cx43）通过缝隙连接和外泌体参与细胞间通讯。此外，质膜上由Cx43形成的半通道对离子稳态和细胞体积调节很重要。通过其在细胞核和线粒体中的定位，Cx43影响各自细胞器的功能。几种心血管疾病，如心力衰竭、缺血/再灌注损伤、肥厚型心肌病和心律失常，其特征是Cx43下调和Cx43功能失调。因此，这些疾病的一种假定治疗方法将包括在受损心脏中诱导Cx43表达，尽管这种诱导可能具有有益和有害的影响。在这篇综述中，我们讨论了增加心脏Cx43表达的后果，并将这种操作作为治疗心血管疾病的一种策略进行讨论。
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