Lo Buglio Gabriele, Cruciani Gianluca, Liotti Marianna, Galli Federica, Lingiardi Vittorio, Tanzilli Annalisa
Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, Via degli Apuli, 1, 00185 Rome, Italy.
Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy.
Healthcare (Basel). 2025 Mar 12;13(6):610. doi: 10.3390/healthcare13060610.
BACKGROUND/OBJECTIVES: Loneliness and social isolation are considered significant social determinants of myocardial infarction (MI) or Takotsubo syndrome (TS). However, research on these factors in MI populations is highly heterogeneous, and evidence regarding TS is sparse. The present scoping review aimed at mapping the extent and breadth of the literature on loneliness and social isolation in individuals with MI or TS.
Following PRISMA-ScR guidelines and JBI methodology, we conducted a systematic search in PubMed, Web of Science, and EBSCO/PsycINFO, supplemented by a manual search, for studies published up to 25 June 2024. Primary research studies on loneliness and/or social isolation in individuals with MI or TS were included based on predefined inclusion and exclusion criteria, with title-abstract and full-text screening.
Sixteen studies met the inclusion criteria, all of which focused on MI. Studies were categorized into three key concepts: loneliness ( = 5), social isolation ( = 7), and both loneliness and social isolation ( = 4). The findings showed that MI impacts subjective experiences and interpersonal relationships, often leading to identity shifts and increased social isolation and loneliness. These factors have been shown to be associated with severe physical health outcomes, including heightened mortality risk; however, these associations appear to be highly mediated by unhealthy lifestyle behaviors. Notably, no studies on TS met the inclusion criteria, highlighting a significant research gap. Additionally, no study explored clinical interventions targeting social isolation or loneliness.
MI has a profound impact on social and emotional well-being, with loneliness and social isolation contributing to severe health outcomes. Further research is needed to understand the impact of these factors on individuals with TS.
背景/目的：孤独和社会隔离被认为是心肌梗死（MI）或应激性心肌病（TS）的重要社会决定因素。然而，关于MI人群中这些因素的研究高度异质性，且关于TS的证据稀少。本范围综述旨在梳理有关MI或TS患者孤独和社会隔离的文献的范围和广度。
遵循PRISMA - ScR指南和JBI方法，我们在PubMed、科学网和EBSCO/PsycINFO中进行了系统检索，并辅以手工检索，以查找截至2024年6月25日发表的研究。根据预定义的纳入和排除标准，纳入关于MI或TS患者孤独和/或社会隔离的原发性研究，并进行标题摘要和全文筛选。
16项研究符合纳入标准，所有这些研究都聚焦于MI。研究分为三个关键概念：孤独（n = 5）、社会隔离（n = 7）以及孤独和社会隔离两者（n = 4）。研究结果表明，MI会影响主观体验和人际关系，常常导致身份转变以及社会隔离和孤独感增加。这些因素已被证明与严重的身体健康结果相关，包括死亡风险升高；然而，这些关联似乎很大程度上由不健康的生活方式行为介导。值得注意的是，没有关于TS的研究符合纳入标准，凸显出显著的研究空白。此外，没有研究探讨针对社会隔离或孤独的临床干预措施。
MI对社会和情感幸福有深远影响，孤独和社会隔离会导致严重的健康后果。需要进一步研究以了解这些因素对TS患者的影响。
