Park Hyeong Jun, Lee Moon Jin, Kim Jiyoun
Department of Physical Therapy, College of Health Science, Gachon University, Incheon 21936, Republic of Korea.
Department of Exercise Rehabilitation, Institute of Human Convergence Health Science, Gachon University, Incheon 13120, Republic of Korea.
Healthcare (Basel). 2025 Mar 12;13(6):613. doi: 10.3390/healthcare13060613.
: Advanced Glycation End Products (AGEs) are high-molecular-weight compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. This study aimed to comprehensively analyze the association between the accumulation of AGEs and lower-limb muscle strength, gait speed, and balance abilities related to mobility in elderly individuals. : This cross-sectional correlational study included 552 community-dwelling older adults. AGE accumulation was assessed using skin autofluorescence (SAF) measured using an AGE reader. Mobility decline factors were evaluated using the sit-to-stand (STS), gait speed (4 m walk tests), single-leg stance (SLS), and Timed Up and Go (TUG) tests. : A comparison of the physical function across the quartile groups revealed that the group with the highest SAF values, Q4, exhibited a general decline in STS, gait speed, SLS, and TUG performance when compared with the other groups ( < 0.001). Spearman's correlation analysis revealed that the SAF-AGEs demonstrated significant negative correlations with STS ( = -0.211, < 0.001), gait speed ( = -0.243, < 0.001) and SLS ( = -0.201, < 0.001). Additionally, TUG showed a significant positive correlation ( = 0.239, < 0.001). In the logistic regression analysis, compared with the Q1 group, the Q4 group had significantly higher odds of low STS performance (odds ratio (OR) = 2.43, = 0.006), slow gait speed (OR = 2.28, = 0.002), low SLS performance (OR = 2.52, = 0.001), and slow TUG (OR = 2.00, = 0.035). The optimal cutoff value of the SAF for mobility decline was 3.15 (area under the curve 0.694; 95% confidence interval: 0.618-0.771). : This study has demonstrated that higher SAF values were associated with decreased lower-limb strength, gait speed, and balance, thereby suggesting that SAF may be a useful screening tool for predicting mobility decline in older adults.
晚期糖基化终末产物（AGEs）是通过糖与蛋白质、脂质或核酸之间的非酶促反应形成的高分子量化合物。本研究旨在全面分析老年人中AGEs积累与下肢肌肉力量、步态速度以及与活动能力相关的平衡能力之间的关联。：这项横断面相关性研究纳入了552名社区居住的老年人。使用AGE阅读器测量的皮肤自发荧光（SAF）来评估AGE积累情况。使用坐立试验（STS）、步态速度（4米步行试验）、单腿站立试验（SLS）和定时起立行走试验（TUG）来评估活动能力下降因素。：对四分位数组的身体功能进行比较发现，SAF值最高的Q4组与其他组相比，STS、步态速度、SLS和TUG表现普遍下降（<0.001）。Spearman相关性分析显示，SAF-AGEs与STS（=-0.211，<0.001）、步态速度（=-0.243，<0.001）和SLS（=-0.201，<0.001）呈显著负相关。此外，TUG呈显著正相关（=0.239，<0.001）。在逻辑回归分析中，与Q1组相比，Q4组STS表现低下（优势比（OR）=2.43，=0.006）、步态速度缓慢（OR=2.28，=0.002）、SLS表现低下（OR=2.52，=0.001）和TUG缓慢（OR=2.00，=0.035）的几率显著更高。SAF预测活动能力下降的最佳截断值为3.15（曲线下面积0.694；95%置信区间：0.618-0.771）。：本研究表明，较高的SAF值与下肢力量、步态速度和平衡能力下降有关，从而表明SAF可能是预测老年人活动能力下降的有用筛查工具。
