Gentry L O, Wood B A, Natelson E A
Antimicrob Agents Chemother. 1985 May;27(5):683-4. doi: 10.1128/AAC.27.5.683.
We investigated the effects of apalcillin on blood coagulation and platelet function. The drug was administered to 21 human volunteers in daily intravenous doses of 75, 150, and 225 mg/kg. These doses evoked abnormalities in platelet aggregation similar to those found with piperacillin and mezlocillin and less striking than those produced by carbenicillin and ticarcillin. Plasma coagulation as measured by prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen concentration was not affected. There were consistent and major reductions in plasma antithrombin III activity, particularly at the two higher dose levels. Of 21 patients, 7 (33%) also manifested maculopapular skin rashes which resolved after discontinuation of the drug.
我们研究了阿帕西林对血液凝固和血小板功能的影响。将该药物以每日静脉注射剂量75、150和225mg/kg给予21名人类志愿者。这些剂量引起的血小板聚集异常与哌拉西林和美洛西林相似，且不如羧苄西林和替卡西林引起的异常明显。通过凝血酶原时间、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原浓度测量的血浆凝血未受影响。血浆抗凝血酶III活性持续且大幅降低，尤其是在两个较高剂量水平。21名患者中有7名（33%）也出现了斑丘疹皮疹，停药后皮疹消退。
