Natelson E A, Siebert W T, Williams T W, Bradshaw M W
Am J Med Sci. 1979 Nov-Dec;278(3):217-21. doi: 10.1097/00000441-197911000-00005.
Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.
对正常志愿者联合静脉输注替卡西林和头孢唑林导致了功能性血小板缺陷，这种缺陷似乎主要由青霉素成分的治疗剂量和持续时间决定。对可溶性血液凝固因子没有明显影响。急性给予皮质类固醇对延长替卡西林输注引起的出血时间延长没有影响。
