Nieder M, Hager L
Arch Biochem Biophys. 1985 Jul;240(1):121-7. doi: 10.1016/0003-9861(85)90014-1.
Pure bromoperoxidase from the marine alga, Penicillus capitatus, converts alpha-amino acids and peptides to the corresponding decarboxylated nitriles and aldehydes in the presence of hydrogen peroxide and bromide ion. Thus, both valine and valylvaline are converted to isobutyronitrile and isobutyraldehyde while alanine is converted to acetonitrile and acetaldehyde. The reaction is nonstereospecific and can be catalyzed by bromoperoxidases obtained from different sources. Bromoperoxidase catalyzes the conversion of methoxytyrosine to p-methoxyphenylacetonitrile. This reaction is consistent with the involvement of bromoperoxidase in the formation of aeroplysinin-1, a brominated aromatic nitrile antibiotic produced by a marine sponge.
来自海洋藻类头状笔螅的纯溴过氧化物酶，在过氧化氢和溴离子存在的情况下，可将α-氨基酸和肽转化为相应的脱羧腈和醛。因此，缬氨酸和缬氨酰缬氨酸都被转化为异丁腈和异丁醛，而丙氨酸则被转化为乙腈和乙醛。该反应是非立体特异性的，可由从不同来源获得的溴过氧化物酶催化。溴过氧化物酶催化甲氧基酪氨酸转化为对甲氧基苯乙腈。该反应与溴过氧化物酶参与一种海洋海绵产生的溴化芳香腈抗生素——气单胞菌素-1的形成相一致。
