针刺对卵巢储备功能下降患者脑活动的影响：一项静息态功能磁共振成像研究
Effect of acupuncture on brain activity in patients with decreasing ovarian reserve: a resting-state functional magnetic resonance imaging study.
作者信息
Tianyu Bai, Jiaen Yang, Liang Yin, Jinling L I, Jianxian Liu, Zongchang L I, Zeming Sun, Ning Jia, Chengchao X U
机构信息
Department of Acupuncture, Moxibustion and Massage, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, China.
Department of Traditional Chinese Medicine, People's Hospital of Gaoming District of Foshan City, Foshan 528500, China.
出版信息
J Tradit Chin Med. 2025 Apr;45(2):450-457. doi: 10.19852/j.cnki.jtcm.2025.02.011.
OBJECTIVE
To examine the variations in brain regions among individuals with decreasing ovarian reserve (DOR) compared to healthy controls using resting-state functional magnetic resonance imaging (rs-fMRI), and to assess the immediate effects of acupuncture stimulation on these brain regions in DOR patients.
METHODS
Twenty patients diagnosed with DOR (DOR group) and twenty healthy controls (HC group) who underwent rs-fMRI scans were included. The DOR group received acupuncture and underwent a subsequent rs-fMRI scan. Amplitude of low-frequency fluctuations (ALFF) analysis was utilized to identify disparities in brain regions between DOR and HC groups, and to evaluate the immediate effects of acupuncture on DOR patients' brain regions. Common brain regions were identified as seed points for functional connectivity (FC) analysis.
RESULTS
In this study, a total of 20 HCs and 20 patients with DOR were initially enrolled. However, due to incomplete personal information, three participants were removed from the HC group. Additionally, two DOR patients experienced symptoms such as physical discomfort and shortness of breath during the MRI scan, leading to their exclusion due to excessive head movement parameters. Consequently, 17 HCs and 16 DOR patients completed the entire study protocol. Comparative analysis revealed that DOR patients exhibited increased ALFF values in the left inferior temporal gyrus (ITG) and middle temporal gyrus (MTG), while ALFF values in the bilateral superior frontal gyrus (SFG), middle frontal gyrus (MFG), and left inferior frontal gyrus (IFG) were decreased compared to HCs. Following acupuncture intervention, ALFF values in the left SFG, MFG, and supplementary motor area (SMA) of DOR patients increased. Furthermore, functional connectivity (FC) analysis demonstrated increased connectivity of the left SFG with the bilateral calcarine sulcus and lingual gyrus post-acupuncture.
CONCLUSION
This study highlights abnormal neural activity in the SFG, MFG, IFG, and ACC in DOR patients compared to HCs. Acupuncture was found to regulate the activity of the SFG, bringing it closer to normal levels, and enhancing its functional connectivity with the bilateral calcarine sulcus and lingual gyrus.
目的
使用静息态功能磁共振成像（rs-fMRI）检查卵巢储备功能下降（DOR）个体与健康对照者之间脑区的差异，并评估针刺刺激对DOR患者这些脑区的即时影响。
方法
纳入20例诊断为DOR的患者（DOR组）和20例接受rs-fMRI扫描的健康对照者（HC组）。DOR组接受针刺治疗并随后进行rs-fMRI扫描。采用低频振幅（ALFF）分析来识别DOR组和HC组之间脑区的差异，并评估针刺对DOR患者脑区的即时影响。将共同的脑区确定为功能连接（FC）分析的种子点。
结果
本研究最初共纳入20例HC和20例DOR患者。然而，由于个人信息不完整，3名参与者被从HC组中剔除。此外，2例DOR患者在MRI扫描期间出现身体不适和呼吸急促等症状，因头部运动参数过多而被排除。因此，17例HC和16例DOR患者完成了整个研究方案。比较分析显示，DOR患者左侧颞下回（ITG）和颞中回（MTG）的ALFF值升高，而与HC相比，双侧额上回（SFG）、额中回（MFG）和左侧额下回（IFG）的ALFF值降低。针刺干预后，DOR患者左侧SFG、MFG和辅助运动区（SMA）的ALFF值升高。此外，功能连接（FC）分析表明，针刺后左侧SFG与双侧距状沟和舌回的连接性增加。
结论
本研究强调了与HC相比，DOR患者在SFG、MFG、IFG和前扣带回（ACC）存在异常神经活动。发现针刺可调节SFG的活动，使其更接近正常水平，并增强其与双侧距状沟和舌回的功能连接。
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