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儿童非对比增强功能性肺部磁共振成像：基于900例自身测量的矩阵铅笔分解（MP-）MRI报告

Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI.

作者信息

Streibel Carmen, Bauman Grzegorz, Bieri Oliver, Pusterla Orso, Stranzinger Enno, Willers C Corin, Curdy Marion, Casaulta Carmen, Frauchiger Bettina Sarah, Korten Insa, Yammine Sophie, Salem Yasmin, Latzin Philipp, Kieninger Elisabeth

机构信息

Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Graduate School for Health Sciences, University of Bern, Bern, Switzerland.

出版信息

Front Pediatr. 2025 Mar 13;13:1519148. doi: 10.3389/fped.2025.1519148. eCollection 2025.

DOI:10.3389/fped.2025.1519148
PMID:40151183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11947945/
Abstract

OBJECTIVES

Functional imaging of the lungs enables a spatially resolved examination of pulmonary ventilation and perfusion. Non-contrast-enhanced (NCE) magnetic resonance imaging (MRI) techniques do not require specialized set-ups (e.g., hyperpolarized gases), but are applicable on standard clinical MRI scanners. Since patients are not exposed to ionizing radiation during the examinations, NCE-MRI is highly attractive for use in pediatrics, especially in children with chronic lung diseases requiring repeated follow-up measurements.

STUDY DESIGN

We report on our own experience of more than 900 NCE-MRI measurements in children over seven years using matrix pencil decomposition (MP-)MRI. We present original data, i.e., clinical cases in which MP-MRI helped in clinical decision-making together with valuable practical points.

RESULTS

At our center, an optimized workflow including a child-friendly setting and automated provision of outcome protocols led to great acceptance of functional NCE-MRI in patients and clinicians. Within this setting, regular MP-MRI measurements were successfully implemented into clinical routine and proved to be very helpful for surveillance and specific clinical decision-making. We present exemplary cases illustrating the potential of NCE-MRI as a diagnostic tool.

CONCLUSION

In this article, we summarize our unique experience of a large number of MP-MRI measurements. We give an overview on our workflow including standardized and automated analysis and reporting. The exemplary cases from different disease groups illustrate its value in the clinical setting. In conclusion, visualizing regional functional deficits and respective underlying pathophysiological nature of lung impairment seems promising for increasing use of NCE-MRI in the future.

摘要

目的

肺部功能成像能够对肺通气和灌注进行空间分辨检查。非对比增强（NCE）磁共振成像（MRI）技术不需要专门的设置（如超极化气体），但可应用于标准临床MRI扫描仪。由于检查过程中患者不接触电离辐射，NCE-MRI在儿科应用中极具吸引力，尤其是对于需要反复进行随访测量的慢性肺部疾病患儿。

研究设计

我们报告了七年来使用矩阵铅笔分解（MP-）MRI对儿童进行900多次NCE-MRI测量的经验。我们展示了原始数据，即MP-MRI有助于临床决策的临床病例以及有价值的实用要点。

结果

在我们中心，一个优化的工作流程，包括对儿童友好的环境和自动提供结果方案，使功能性NCE-MRI在患者和临床医生中得到了广泛认可。在此环境下，常规的MP-MRI测量成功纳入临床常规，并被证明对监测和特定临床决策非常有帮助。我们展示了一些示例病例，说明NCE-MRI作为诊断工具的潜力。

结论

在本文中，我们总结了大量MP-MRI测量的独特经验。我们概述了我们的工作流程，包括标准化和自动化分析及报告。来自不同疾病组的示例病例说明了其在临床环境中的价值。总之，可视化区域性功能缺陷以及肺损伤各自潜在的病理生理本质，对于未来增加NCE-MRI的使用似乎很有前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/e302a3828bcc/fped-13-1519148-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/5ef1f6be5334/fped-13-1519148-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/946397b237f4/fped-13-1519148-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/07b7866ceb9e/fped-13-1519148-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/a82be4bbf946/fped-13-1519148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/25bc29f6f1da/fped-13-1519148-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/e302a3828bcc/fped-13-1519148-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/5ef1f6be5334/fped-13-1519148-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/d28610983d79/fped-13-1519148-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/1d04b79a6023/fped-13-1519148-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/946397b237f4/fped-13-1519148-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/07b7866ceb9e/fped-13-1519148-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/a82be4bbf946/fped-13-1519148-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/25bc29f6f1da/fped-13-1519148-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62b/11947945/e302a3828bcc/fped-13-1519148-g008.jpg

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Magnetic Resonance Imaging of Lung Perfusion.肺部灌注磁共振成像。
J Magn Reson Imaging. 2024 Mar;59(3):784-796. doi: 10.1002/jmri.28912. Epub 2023 Jul 19.
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