Zhang Junyan, Xie Huancheng, Huang Yuyi
Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 250 Changgang East Road, Haizhu District, Guangzhou 510260, China.
J Clin Biochem Nutr. 2025 Mar;76(2):187-194. doi: 10.3164/jcbn.24-161. Epub 2024 Oct 17.
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is associated with various comorbidities, such as allergic diseases like allergic rhinitis. However, the causal relationship and potential metabolic mechanisms remain unclear. This study investigates the association between inflammatory bowel disease and allergic rhinitis, focusing on potential metabolic mediation through Mendelian randomization analysis. A two-sample Mendelian randomization analysis was conducted using datasets from European populations to evaluate the relationships between inflammatory bowel disease, Crohn's disease, ulcerative colitis, and allergic rhinitis. Additionally, 212 potential mediating metabolites were analyzed to explore metabolic mechanisms. Horizontal pleiotropy was excluded, and mediation analysis identified specific metabolites mediating these effects. Results revealed a significant association between inflammatory bowel disease, Crohn's disease, and allergic rhinitis, while ulcerative colitis showed no significant impact. Further analysis confirmed a unidirectional causal relationship from inflammatory bowel disease and Crohn's disease to allergic rhinitis. Metabolite analysis identified 91 significant metabolites, with 67 showing consistent effects. Notably, erythritol, 1-myristoyl-2-arachidonoyl-GPC, and the 3-methyl-2-oxovalerate to 4-methyl-2-oxopentanoate ratio exhibited significant mediation effects. These findings highlight a significant causal link between inflammatory bowel disease, particularly Crohn's disease, and allergic rhinitis, mediated by specific metabolites, offering new insights and potential targets for clinical interventions.
炎症性肠病，包括克罗恩病和溃疡性结肠炎，与多种合并症相关，如过敏性鼻炎等过敏性疾病。然而，因果关系和潜在的代谢机制仍不清楚。本研究调查炎症性肠病与过敏性鼻炎之间的关联，重点关注通过孟德尔随机化分析的潜在代谢介导作用。使用来自欧洲人群的数据集进行了两样本孟德尔随机化分析，以评估炎症性肠病、克罗恩病、溃疡性结肠炎和过敏性鼻炎之间的关系。此外，分析了212种潜在的介导代谢物以探索代谢机制。排除了水平多效性，中介分析确定了介导这些效应的特定代谢物。结果显示炎症性肠病、克罗恩病与过敏性鼻炎之间存在显著关联，而溃疡性结肠炎未显示出显著影响。进一步分析证实了从炎症性肠病和克罗恩病到过敏性鼻炎的单向因果关系。代谢物分析确定了91种显著代谢物，其中67种显示出一致的效应。值得注意的是，赤藓糖醇、1-肉豆蔻酰-2-花生四烯酰-GPC以及3-甲基-2-氧代戊酸与4-甲基-2-氧代戊酸的比值表现出显著的中介作用。这些发现突出了炎症性肠病，特别是克罗恩病，与过敏性鼻炎之间由特定代谢物介导的显著因果联系，为临床干预提供了新的见解和潜在靶点。
