Zhang Junyan, Wang Songsheng, Huang Yu-Yi
Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 250 Changgang East Road, Haizhu District, Guangzhou 510260, China.
NLP2CT Lab, University of Macau, Avenida da Universidade Taipa, Macau, China.
J Clin Biochem Nutr. 2025 Mar;76(2):156-163. doi: 10.3164/jcbn.24-172. Epub 2024 Dec 27.
The causal relationship between family history of lung cancer and allergic rhinitis remains unclear. This study aimed to explore the association between family history of lung cancer and allergic rhinitis, along with potential mediating mechanisms, using Mendelian randomization.
A bidirectional two-sample Mendelian randomization analysis was conducted to assess the causal relationship between family history of lung cancer (including parental, paternal, maternal, and sibling histories) and allergic rhinitis, using genetic variants associated with family history of lung cancer as instrumental variables. Additionally, mediation Mendelian randomization analysis was performed to investigate the role of specific metabolites in mediating this relationship.
The analysis revealed a significant causal relationship between parental history of lung cancer and allergic rhinitis, with maternal lung cancer history showing a strong protective effect against allergic rhinitis (OR = 0.28, <0.05). Mediation analysis further indicated that metabolites such as 1-linoleoyl-GPE (18:2) and -palmitoyl-sphingosine exhibited negative mediating effects in the association between maternal lung cancer and allergic rhinitis. Lower levels of these metabolites enhanced the protective effect of maternal lung cancer history on allergic rhinitis.
This study demonstrates a significant causal relationship between maternal lung cancer history and allergic rhinitis, with specific metabolites potentially playing a mediating role. Changes in the levels of 1-linoleoyl-GPE (18:2) and -palmitoyl-sphingosine are associated with the protective effect of maternal lung cancer history on allergic rhinitis, suggesting that metabolites may be crucial in regulating this relationship. These findings provide new insights into the relationship between family history of lung cancer and immune-related diseases, offering potential directions for future clinical prevention and treatment strategies.
肺癌家族史与过敏性鼻炎之间的因果关系尚不清楚。本研究旨在利用孟德尔随机化方法探讨肺癌家族史与过敏性鼻炎之间的关联及其潜在的中介机制。
进行双向两样本孟德尔随机化分析，以评估肺癌家族史（包括父母、父亲、母亲和兄弟姐妹的家族史）与过敏性鼻炎之间的因果关系，使用与肺癌家族史相关的基因变异作为工具变量。此外，进行中介孟德尔随机化分析以研究特定代谢物在介导这种关系中的作用。
分析显示父母肺癌家族史与过敏性鼻炎之间存在显著的因果关系，母亲肺癌家族史对过敏性鼻炎具有很强的保护作用（OR = 0.28，<0.05）。中介分析进一步表明，1-亚油酰基-GPE（18:2）和-棕榈酰鞘氨醇等代谢物在母亲肺癌与过敏性鼻炎的关联中表现出负向中介作用。这些代谢物水平较低增强了母亲肺癌家族史对过敏性鼻炎的保护作用。
本研究表明母亲肺癌家族史与过敏性鼻炎之间存在显著的因果关系，特定代谢物可能起中介作用。1-亚油酰基-GPE（18:2）和-棕榈酰鞘氨醇水平的变化与母亲肺癌家族史对过敏性鼻炎的保护作用相关，表明代谢物可能在调节这种关系中起关键作用。这些发现为肺癌家族史与免疫相关疾病之间的关系提供了新的见解，为未来临床预防和治疗策略提供了潜在方向。
